SCHEMBL2037067

SCHEMBL2037067

C=C(C)C(=O)Oc1cccc(N2C(=O)CCC2=O)c1

nearest known ligand 0.72

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 8/20 0.72
▸ ATM Q13315 1/20 0.72
▸ MAPK1 P28482 1/20 0.56
▸ MAPT P10636 3/20 0.50
▸ GLA P06280 1/20 0.50
▸ L3MBTL1 Q9Y468 1/20 0.50
▸ MEN1 O00255 2/20 0.47
▸ ALDH1A1 P00352 4/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ CACNA1B Q00975 1/20 0.43
▸ APBA1 Q02410 1/20 0.43
▸ HSD17B10 Q99714 2/20 0.42
▸ HTT P42858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13133152 0.84 MGLL (0.58) KMT2AATMMEN1ALDH1A1CACNA1B
SCHEMBL2031643 0.84 KMT2A (1.00) KMT2AATMMAPK1GLAMEN1
SCHEMBL218655 0.79 ELANE (0.56) KMT2AATMMEN1ALDH1A1
SCHEMBL14173262 0.75 ELANE (0.51) KMT2AATMMAPTMEN1ALDH1A1
SCHEMBL26846471 0.75 LMNA (0.59) KMT2AATMMAPTMEN1ALDH1A1
SCHEMBL379060 0.75 ELANE (0.51) KMT2AATMMAPTMEN1
SCHEMBL7186457 0.73 CES2 (0.50) KMT2AMAPTMEN1ALDH1A1SMN1; SMN2
SCHEMBL1756084 0.73 CYP3A4 (0.50) KMT2AATMMAPTMEN1ALDH1A1
SCHEMBL1347701 0.73 LMNA (0.68) KMT2AATMMAPK1MAPTMEN1
SCHEMBL31097939 0.73 CYP3A4 (0.68) KMT2AATMMEN1ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3004050-B1 CYANOSTILBENES ROLIC TECH AG (CH) 2020-09-02 — — EP disclosed
CN-111533668-A Cyanostilbenes 罗利克技术有限公司 2020-08-14 — — CN disclosed
US-10329486-B2 Cyanostilbenes ROLIC AG (CH) 2019-06-25 — — US disclosed
EP-3004050-A1 CYANOSTILBENES Rolic AG (CH) 2016-04-13 — — EP disclosed
US-20160083655-A1 CYANOSTILBENES ROLIC AG (CH) 2016-03-24 — — US disclosed
WO-2014191292-A1 CYANOSTILBENES ROLIC AG (CH) 2014-12-04 — — WO disclosed
US-7959990-B2 Adjustment of liquid crystals; oligomers, dendrimers, or polymer in solution is applied to support; crosslinking by radiation or polarized light ROLIC AG (CH) 2011-06-14 — — US disclosed
EP-1928979-B1 FUNCTIONALIZED PHOTOREACTIVE COMPOUNDS ROLIC AG (CH) 2009-03-04 — — EP disclosed
US-20080274304-A1 Functionalized Photoreactive Compounds ROLIC AG (CH) 2008-11-06 — — US disclosed
EP-1928979-A1 FUNCTIONALIZED PHOTOREACTIVE COMPOUNDS Rolic AG (CH) 2008-06-11 — — EP disclosed
WO-2007033506-A1 FUNCTIONALIZED PHOTOREACTIVE COMPOUNDS ROLIC AG (CH) 2007-03-29 — — WO disclosed
EP-1764405-A1 Functionalized photoreactive compounds Rolic AG (CH) 2007-03-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080274304-A1 Functionalized Photoreactive Compounds PCNA, PIN1, MAP1LC3C KMT2A 3167/4885ATM 4135/4885MAPK1 570/4885
US-20160083655-A1 CYANOSTILBENES LATS1, LATS2, CRY1 KMT2A 2902/4885ATM 1522/4885MAPK1 984/4885
US-10329486-B2 Cyanostilbenes LATS1, LATS2, CRY1 KMT2A 2902/4885ATM 1522/4885MAPK1 984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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