Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 2/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 3/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373449 | 0.85 | SYK (0.38) | TLR7SYKNOX4ALOX5AP | |
| SCHEMBL20373284 | 0.83 | KDM4E (0.36) | TLR7SYKKDM4EALDH1A1NOX4 | |
| SCHEMBL20373588 | 0.83 | BRD4 (0.37) | TLR7NOX4 | |
| SCHEMBL20373360 | 0.83 | MET (0.40) | POLBKDM4EALDH1A1L3MBTL1MCHR1 | |
| SCHEMBL20373357 | 0.81 | NOX4 (0.43) | POLBKDM4EALDH1A1NOX4MCHR1 | |
| SCHEMBL20373445 | 0.81 | TLR7 (0.33) | GABRA1GABRA5TLR7SYKKDM4E | |
| SCHEMBL20373452 | 0.81 | KCNA5 (0.40) | GABRA1GABRA5TLR7SYKNOX4 | |
| SCHEMBL20373754 | 0.79 | TLR7 (0.37) | GABRA1GABRA5TLR7KDM4ENOX4 | |
| SCHEMBL16906060 | 0.78 | BRD4 (0.48) | — | |
| SCHEMBL20373288 | 0.77 | S1PR3 (0.37) | KDM4EALDH1A1KCNH2NOX4MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |