Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | GPR3 | P46089 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254957 | 0.86 | MAPT (0.56) | MAPTEPHX2GPR3L3MBTL1KDM4E | |
| SCHEMBL80634 | 0.79 | TRPV1 (0.58) | MAPTEPHX2GPR3L3MBTL1KDM4E | |
| SCHEMBL28780452 | 0.78 | EPHX2 (0.50) | MAPTEPHX2GPR3L3MBTL1KDM4E | |
| SCHEMBL19287491 | 0.77 | CETP (0.44) | GPR3KIF11PIM1PIM2 | |
| SCHEMBL13863723 | 0.76 | MAPT (0.48) | MAPTEPHX2GPR3L3MBTL1KDM4E | |
| SCHEMBL255560 | 0.76 | GPR3 (0.52) | MAPTEPHX2GPR3L3MBTL1KDM4E | |
| SCHEMBL15372299 | 0.74 | MAPT (0.47) | MAPTEPHX2GPR3L3MBTL1KDM4E | |
| SCHEMBL97453 | 0.74 | MAPT (0.47) | MAPTEPHX2GPR3L3MBTL1KDM4E | |
| SCHEMBL221511 | 0.74 | MAPT (0.52) | MAPTEPHX2GPR3L3MBTL1KDM4E | |
| SCHEMBL7007579 | 0.74 | MAPT (0.47) | MAPTEPHX2GPR3L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023538-B2 | Compounds, compositions and associated methods comprising 3-aryl quinolines | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2018-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023538-B2 | Compounds, compositions and associated methods comprising 3-aryl quinolines | CYP3A43, ABL1, CYP3A7 | MAPT 1216/4885EPHX2 1197/4885GPR3 1164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.