Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191996 | 0.80 | ACHE (0.59) | HTR2AHTR2CHTR2BPTGS2CYP19A1 | |
| Alcohol SCHEMBL9525249 | 0.79 | PTGS2 (0.54) | HTR2AHTR2CHTR2BPTGS2CYP19A1 | |
| Hydrochloric Acid SCHEMBL4381078 | 0.78 | ACHE (0.56) | HTR2AHTR2CHTR2BPTGS2CYP19A1 | |
| Ammonia Solution, Strong SCHEMBL4946565 | 0.78 | ACHE (0.56) | HTR2AHTR2CHTR2BPTGS2CYP19A1 | |
| SCHEMBL5514786 | 0.72 | PTGS2 (0.61) | HTR2AHTR2CHTR2BALOX5PTGS2 | |
| SCHEMBL13359272 | 0.72 | PTGS2 (0.50) | HTR2AHTR2CHTR2BPTGS2CYP19A1 | |
| SCHEMBL16295765 | 0.72 | HTR2A (0.78) | HTR2AHTR2CHTR2BPTGS2CYP19A1 | |
| SCHEMBL22864010 | 0.71 | HTR2A (0.66) | HTR2AHTR2CHTR2BPTGS2CYP19A1 | |
| SCHEMBL1766178 | 0.71 | HTR2A (0.44) | HTR2AHTR2CHTR2BPTGS2CYP19A1 | |
| SCHEMBL7511994 | 0.71 | GAA (0.63) | HTR2AHTR2CHTR2BPTGS2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309734-A1 | COMBRETASTATIN DERIVATIVES AND USES THEREFOR | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2012-12-06 | — | — | US | disclosed |
| EP-2513051-A1 | COMBRETASTATIN DERIVATIVES AND USES THEREFOR | The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin (IE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2338877-A1 | Combretastatin Derivatives and Uses Therefor | The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin (IE) | 2011-06-29 | — | — | EP | disclosed |
| WO-2011073211-A1 | COMBRETASTATIN DERIVATIVES AND USES THEREFOR | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309734-A1 | COMBRETASTATIN DERIVATIVES AND USES THEREFOR | CASP4, CA4, ACSL4 | HTR2A 4772/4885HTR2C 4789/4885HTR2B 3905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.