Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.30 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23961617 | 1.00 | CA12 (0.36) | CA12CA1CA2CA4CA9 | |
| SCHEMBL24087858 | 0.97 | OPRK1 (0.35) | CA12CA1CA2CA4CA9 | |
| SCHEMBL19026314 | 0.94 | CA12 (0.36) | CA12CA1CA2CA4CA9 | |
| SCHEMBL23071798 | 0.93 | MGLL (0.37) | CA12CA1CA2CA4CA9 | |
| SCHEMBL18264893 | 0.90 | OPRK1 (0.35) | CA12CA1CA2CA4CA9 | |
| SCHEMBL23846023 | 0.89 | NR3C1 (0.38) | CA12CA1CA2CA4CA9 | |
| SCHEMBL23961616 | 0.89 | NR3C1 (0.38) | CA12CA1CA2CA4CA9 | |
| SCHEMBL24898123 | 0.89 | NR3C1 (0.38) | CA12CA1CA2CA4CA9 | |
| SCHEMBL24788071 | 0.89 | LMNA (0.35) | CA12CA1CA2CA4CA9 | |
| SCHEMBL18929515 | 0.87 | OPRK1 (0.31) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10029018-B2 | Pyrrolobenzodiazepines and conjugates thereof | MEDIMMUNE LIMITED (GB) | 2018-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10029018-B2 | Pyrrolobenzodiazepines and conjugates thereof | DBH, DDO, DOHH | CA12 1879/4885CA1 1231/4885CA2 2956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.