Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | IL2 | P60568 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10165367 | 0.86 | GPR84 (0.46) | MAPK1GPR84FFAR1HTR2AALB | |
| SCHEMBL849137 | 0.83 | MAPK1 (0.58) | MAPK1GPR84PIM3NR4A2HTR1D | |
| SCHEMBL29051448 | 0.83 | MAPK1 (0.58) | MAPK1GPR84PIM3HTR2ANR4A2 | |
| SCHEMBL3676955 | 0.83 | NR4A2 (0.60) | MAPK1GPR84PIM3NR4A2HTR1D | |
| SCHEMBL2034897 | 0.81 | GPR84 (0.51) | GPR84FFAR1HTR2AALBIL2 | |
| SCHEMBL23160620 | 0.80 | GPR84 (0.50) | MAPK1GPR84FFAR1HTR2AALB | |
| SCHEMBL16234666 | 0.80 | PBRM1 (0.54) | MAPK1GPR84FFAR1HTR2AALB | |
| SCHEMBL10321304 | 0.80 | ALDH1A1 (0.54) | MAPK1GPR84FFAR1PIM3HTR2A | |
| SCHEMBL1558360 | 0.79 | HTR2A (0.49) | GPR84FFAR1HTR2AALBIL2 | |
| SCHEMBL10078403 | 0.79 | HTR2A (0.49) | MAPK1GPR84FFAR1HTR2AALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210101881-A1 | PYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL (SHANGHAI) CO., LTD. (CN) | 2021-04-08 | — | — | US | disclosed |
| US-20210101881-A1 | PYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL (SHANGHAI) CO., LTD. (CN) | 2021-04-08 | — | — | US | disclosed |
| CN-108026073-B | Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators | 苏文生命科学有限公司 | 2020-09-22 | — | — | CN | disclosed |
| CN-111566100-A | Pyrimidine compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2020-08-21 | — | — | CN | disclosed |
| EP-3347349-B1 | FLUOROINDOLE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LTD (IN) | 2019-09-18 | — | — | EP | disclosed |
| EP-3347349-B1 | FLUOROINDOLE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LTD (IN) | 2019-09-18 | — | — | EP | disclosed |
| WO-2019154177-A1 | PYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF | 恩瑞生物医药科技（上海）有限公司 | 2019-08-15 | — | — | WO | disclosed |
| WO-2019154177-A1 | PYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF | 恩瑞生物医药科技（上海）有限公司 | 2019-08-15 | — | — | WO | disclosed |
| US-10294217-B2 | Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators | SUVEN LIFE SCIENCES LIMITED (IN) | 2019-05-21 | — | — | US | disclosed |
| US-10294217-B2 | Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators | SUVEN LIFE SCIENCES LIMITED (IN) | 2019-05-21 | — | — | US | disclosed |
| US-20180244655-A1 | Fluoroindole Derivatives as Muscarinic M1 Receptor Positive Allosteric Modulators | SUVEN LIFE SCIENCES LIMITED (IN) | 2018-08-30 | — | — | US | disclosed |
| EP-3347349-A1 | FLUOROINDOLE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Suven Life Sciences Limited (IN) | 2018-07-18 | — | — | EP | disclosed |
| WO-2017042643-A1 | FLUOROINDOLE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LIMITED (IN) | 2017-03-16 | — | — | WO | disclosed |
| WO-2017042643-A1 | FLUOROINDOLE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LIMITED (IN) | 2017-03-16 | — | — | WO | disclosed |
| EP-2516419-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2012-10-31 | — | — | EP | disclosed |
| US-20120245161-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| US-20120245161-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| US-20120245161-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| WO-2011079102-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079102-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10294217-B2 | Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators | CHRM1, CHRM2, CHRM3 | MAPK1 1050/4885GPR84 69/4885FFAR1 74/4885 |
| US-20120245161-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | TPSAB1, TPSB2, TPSD1 | MAPK1 3381/4885GPR84 589/4885FFAR1 2143/4885 |
| US-20210101881-A1 | PYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF | CDK9, CDK19, CDK6 | MAPK1 520/4885GPR84 3385/4885FFAR1 4687/4885 |
| US-20180244655-A1 | Fluoroindole Derivatives as Muscarinic M1 Receptor Positive Allosteric Modulators | CHRM1, CHRM2, CHRM3 | MAPK1 1050/4885GPR84 69/4885FFAR1 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.