Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17615540 | 0.79 | PTPN1 (0.47) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL10216166 | 0.79 | PTPN1 (0.44) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL23478524 | 0.78 | ALDH1A1 (0.44) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL22672437 | 0.76 | TBK1 (0.48) | GAAPTPN1MAPTKDM4EALOX15 | |
| SCHEMBL4247045 | 0.74 | KDM4E (0.54) | ALDH1A1HTTGAAMAPTTP53 | |
| SCHEMBL29972769 | 0.74 | KDM4E (0.54) | ALDH1A1HTTGAAMAPTTP53 | |
| SCHEMBL22185375 | 0.73 | PIN1 (0.59) | PTGS1ALDH1A1HTTGAAHIF1A | |
| SCHEMBL28238868 | 0.71 | PTPN1 (0.48) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL2706167 | 0.71 | BCHE (0.45) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL4416630 | 0.70 | ALOX15 (0.37) | ALDH1A1ALOX12PTPN1TYRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180208602-A1 | NEW BICYCLIC COMPOUNDS AS ATX INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2018-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180208602-A1 | NEW BICYCLIC COMPOUNDS AS ATX INHIBITORS | ATXN2, ATXN10, ATXN2L | TRPA1 3695/4885PTGS1 3520/4885CACNA1C 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.