Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 9/20 | 0.50 |
| ▸ | CTSK | P43235 | 9/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20416723 | 0.93 | CYP19A1 (0.43) | CTSSCTSKCYP19A1KLKB1HDAC2 | |
| SCHEMBL20416734 | 0.88 | CYP19A1 (0.41) | CTSSCTSKCYP19A1KLKB1HDAC2 | |
| SCHEMBL30401212 | 0.88 | CYP19A1 (0.41) | CTSSCTSKCYP19A1KLKB1HDAC2 | |
| SCHEMBL20416807 | 0.88 | CTSS (0.51) | CTSSCTSKCYP19A1ADORA2BADORA2A | |
| SCHEMBL20436696 | 0.86 | KLKB1 (0.41) | CTSSCTSKCYP19A1KLKB1HDAC2 | |
| SCHEMBL20436712 | 0.85 | ADORA2B (0.45) | CTSSCTSKCYP19A1KLKB1HDAC2 | |
| SCHEMBL20417073 | 0.83 | KLKB1 (0.39) | CTSSCTSKCYP19A1KLKB1HDAC2 | |
| SCHEMBL30401933 | 0.83 | KLKB1 (0.39) | CTSSCTSKCYP19A1KLKB1HDAC2 | |
| SCHEMBL20417081 | 0.83 | CYP19A1 (0.39) | CTSSCTSKCYP19A1KLKB1HDAC2 | |
| SCHEMBL20436697 | 0.82 | LRRK2 (0.39) | CYP19A1KLKB1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4310082-A2 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | Arcus Biosciences, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| EP-3570844-B1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES INC (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2018136700-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES, INC. (US) | 2018-07-26 | — | — | WO | disclosed |