Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | CA5A | P35218 | 3/20 | 0.35 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13735316 | 0.90 | ALDH1A1 (0.37) | ALDH1A1CYP3A4MEN1HSP90AA1KMT2A | |
| SCHEMBL6268161 | 0.82 | PDE4A (0.39) | ALDH1A1MEN1KMT2APDE4APDE4C | |
| SCHEMBL5108192 | 0.81 | ALDH1A1 (0.41) | ALDH1A1CYP3A4MEN1KMT2APDE4A | |
| SCHEMBL2048625 | 0.81 | ALDH1A1 (0.47) | ALDH1A1CYP3A4KMT2APDE4APDE4C | |
| SCHEMBL3434140 | 0.79 | EPAS1 (0.37) | ALDH1A1CYP3A4PDE4APDE4CPDE4D | |
| SCHEMBL3141207 | 0.79 | HSPB1 (0.44) | ALDH1A1MEN1KMT2AMAPTHTT | |
| Potassium Ion SCHEMBL10721890 | 0.78 | ALDH1A1 (0.44) | ALDH1A1CYP3A4MEN1HSP90AA1KMT2A | |
| SCHEMBL2042973 | 0.77 | CYP1A2 (0.45) | ALDH1A1KMT2APDE4APDE4CPDE4D | |
| SCHEMBL3434996 | 0.77 | MAPT (0.43) | ALDH1A1CYP3A4MEN1KMT2AMAPT | |
| SCHEMBL12584980 | 0.75 | ALDH1A1 (0.41) | ALDH1A1CYP3A4MEN1KMT2APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050054873-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2005-03-10 | — | — | US | claimed |
| US-20030157671-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2003-08-21 | — | — | US | claimed |
| WO-2003039456-A2 | PROCESS FOR THE PREPARATION OF ANILINE-DERIVED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-05-15 | — | — | WO | claimed |
| US-7956214-B2 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2011-06-07 | — | — | US | disclosed |
| US-20090326263-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | CHIDAMBARAM RAMAKRISHNAN | 2009-12-31 | — | — | US | disclosed |
| US-20050054873-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2005-03-10 | — | — | US | disclosed |
| US-6806381-B2 | SUCH AS N-(3,5-DIBROMO-4-(4-HYDROXY-3-ISOPROPYL-PHENOXY)-PHENYL)-MALONAMIC ACID; FOR TREATMENT OF THYROID DISORDERS | BRISTOL-MYERS SQUIBB COMPANY | 2004-10-19 | — | — | US | disclosed |
| US-20040176425-A1 | Cycloalkyl containing anilide ligands for the thyroid receptor | BRISTOL-MYERS SQUIBB COMPANY | 2004-09-09 | — | — | US | disclosed |
| US-20030157671-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2003-08-21 | — | — | US | disclosed |
| WO-2003039456-A2 | PROCESS FOR THE PREPARATION OF ANILINE-DERIVED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176425-A1 | Cycloalkyl containing anilide ligands for the thyroid receptor | TSHR, THRB, TRHR | ALDH1A1 1691/4885CYP3A4 3301/4885MEN1 3912/4885 |
| US-20050054873-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | TSHR, THRA, THRB | ALDH1A1 816/4885CYP3A4 225/4885MEN1 1504/4885 |
| US-20090326263-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | TSHR, THRA, THRB | ALDH1A1 816/4885CYP3A4 225/4885MEN1 1504/4885 |
| US-20030157671-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | TSHR, THRA, THRB | ALDH1A1 816/4885CYP3A4 225/4885MEN1 1504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.