Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3434996 | 0.78 | MAPT (0.43) | ALDH1A1PTPN1MAPTL3MBTL1KMT2A | |
| SCHEMBL3434140 | 0.78 | EPAS1 (0.37) | ALDH1A1TDP1TSHRPTPN1MAPT | |
| SCHEMBL2041908 | 0.77 | ALDH1A1 (0.41) | ALDH1A1TSHRMAPTKMT2APDE4A | |
| SCHEMBL13735316 | 0.77 | ALDH1A1 (0.37) | ALDH1A1TDP1TSHRMAPTKMT2A | |
| SCHEMBL700219 | 0.76 | CYP1A2 (0.56) | CYP1A2ALDH1A1TDP1TSHRMAPT | |
| SCHEMBL29369262 | 0.76 | CYP1A2 (0.56) | CYP1A2ALDH1A1TDP1TSHRMAPT | |
| SCHEMBL2050119 | 0.76 | TDP1 (0.39) | CYP1A2ALDH1A1TDP1TSHRPTPN1 | |
| SCHEMBL7392580 | 0.73 | TSHR (0.40) | ALDH1A1TDP1TSHRPTPN1MAPT | |
| SCHEMBL29051556 | 0.73 | HSPB1 (0.38) | CYP1A2ALDH1A1TDP1TSHRPTPN1 | |
| SCHEMBL15287612 | 0.73 | ALDH1A1 (0.33) | ALDH1A1EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050054873-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2005-03-10 | — | — | US | claimed |
| US-20030157671-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2003-08-21 | — | — | US | claimed |
| US-7956214-B2 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2011-06-07 | — | — | US | disclosed |
| US-20090326263-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | CHIDAMBARAM RAMAKRISHNAN | 2009-12-31 | — | — | US | disclosed |
| US-20050054873-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2005-03-10 | — | — | US | disclosed |
| US-6806381-B2 | SUCH AS N-(3,5-DIBROMO-4-(4-HYDROXY-3-ISOPROPYL-PHENOXY)-PHENYL)-MALONAMIC ACID; FOR TREATMENT OF THYROID DISORDERS | BRISTOL-MYERS SQUIBB COMPANY | 2004-10-19 | — | — | US | disclosed |
| US-20030157671-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | KARO BIO AB (SE) | 2003-08-21 | — | — | US | disclosed |
| WO-2003039456-A2 | PROCESS FOR THE PREPARATION OF ANILINE-DERIVED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054873-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | TSHR, THRA, THRB | CYP1A2 200/4885ALDH1A1 816/4885TDP1 3223/4885 |
| US-20090326263-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | TSHR, THRA, THRB | CYP1A2 200/4885ALDH1A1 816/4885TDP1 3223/4885 |
| US-20030157671-A1 | Process for the preparation of aniline-derived thyroid receptor ligands | TSHR, THRA, THRB | CYP1A2 200/4885ALDH1A1 816/4885TDP1 3223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.