Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17078847 | 0.88 | HDAC6 (0.55) | HDAC1HDAC6POLB | |
| SCHEMBL17078608 | 0.88 | MEN1 (0.47) | HDAC1HDAC6POLBGAAL3MBTL1 | |
| SCHEMBL17078470 | 0.81 | FAAH (0.50) | HDAC1HDAC6KDM4EMAPTLTA4H | |
| SCHEMBL20420898 | 0.81 | CACNA1G (0.48) | HDAC1HDAC6POLBSMN1; SMN2KMT2A | |
| SCHEMBL20420923 | 0.80 | ALDH1A1 (0.45) | HDAC1HDAC6POLBGAASMN1; SMN2 | |
| SCHEMBL20420964 | 0.80 | POLB (0.45) | HDAC1HDAC6POLBGAASMN1; SMN2 | |
| SCHEMBL20420995 | 0.78 | PLA2G1B (0.55) | HDAC1HDAC6POLBGAASMN1; SMN2 | |
| SCHEMBL20421118 | 0.78 | SMN1; SMN2 (0.47) | GAASMN1; SMN2L3MBTL1KMT2AKDM4E | |
| SCHEMBL20421054 | 0.77 | HDAC1 (0.46) | HDAC1HDAC6POLBGAASMN1; SMN2 | |
| SCHEMBL20421200 | 0.77 | HSD11B1 (0.47) | HDAC1HDAC6POLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116859-B1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2018-08-01 | — | — | EP | disclosed |