Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17078918 | 0.88 | HDAC6 (0.55) | POLBHDAC1HDAC6 | |
| SCHEMBL17078810 | 0.88 | MEN1 (0.50) | POLBGAASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL20421051 | 0.83 | GAA (0.43) | POLBKDM1AHDAC1HDAC6GAA | |
| SCHEMBL20420962 | 0.82 | FAAH (0.51) | POLBKDM1AKDM4EMAPTHIF1A | |
| SCHEMBL20420921 | 0.81 | ALDH1A1 (0.46) | POLBKDM1AHDAC1HDAC6GAA | |
| SCHEMBL20421014 | 0.81 | POLB (0.46) | POLBKDM1AHDAC1HDAC6GAA | |
| SCHEMBL20420932 | 0.81 | CACNA1G (0.56) | — | |
| SCHEMBL20420895 | 0.80 | HDAC1 (0.42) | POLBHDAC1HDAC6GAASMN1; SMN2 | |
| SCHEMBL20420925 | 0.79 | S1PR5 (0.45) | POLBKDM1AHDAC1HDAC6GAA | |
| SCHEMBL20420940 | 0.78 | LTA4H (0.49) | POLBKDM1AHDAC1HDAC6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116859-B1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2018-08-01 | — | — | EP | disclosed |