Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Oxyquinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.81 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.81 |
| ▸ | MMP2 | P08253 | 2/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.81 |
| ▸ | COMT | P21964 | 1/20 | 0.81 |
| ▸ | METAP2 | P50579 | 1/20 | 0.81 |
| ▸ | METAP1 | P53582 | 1/20 | 0.81 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.73 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxyquinoline SCHEMBL7261596 | 1.00 | TSHR (0.81) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL28194203 | 0.98 | TSHR (0.78) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL3070563 | 0.93 | TSHR (0.70) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL29100488 | 0.93 | MMP2 (0.75) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL29365411 | 0.90 | TSHR (1.00) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL29716519 | 0.90 | TSHR (1.00) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL37189 | 0.90 | TSHR (1.00) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL253313 | 0.90 | TSHR (1.00) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL15266589 | 0.90 | MMP2 (0.70) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL7187630 | 0.88 | TSHR (0.88) | TSHRMMP2CHRM1COMTADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107356742-B | Method for rapidly detecting angiotensin I in batches | 广州金域医学检验中心有限公司 | 2020-04-10 | — | — | CN | claimed |
| CN-107356742-A | The method that rapid batch detects angiotensin I | 广州金域医学检验中心有限公司 | 2017-11-17 | — | — | CN | claimed |
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | claimed |
| CN-118956200-A | PO43-8-OQ intercalated zinc-aluminum hydrotalcite and PO43-Preparation method of 8-OQ intercalated zinc-aluminum hydrotalcite flame-retardant epoxy acrylic acid coating and coating thereof | 莆田学院 | 2024-11-15 | — | — | CN | disclosed |
| US-10959937-B2 | Oil-in-water type organopolysiloxane emulsion and method for producing same, cosmetic raw material, and cosmetic product | DOW TORAY CO., LTD. (JP) | 2021-03-30 | — | — | US | disclosed |
| CN-107356742-B | Method for rapidly detecting angiotensin I in batches | 广州金域医学检验中心有限公司 | 2020-04-10 | — | — | CN | disclosed |
| US-20180280283-A1 | OIL-IN-WATER TYPE ORGANOPOLYSILOXANE EMULSION AND METHOD FOR PRODUCING SAME, COSMETIC RAW MATERIAL, AND COSMETIC PRODUCT | DOW TORAY CO., LTD. (JP) | 2018-10-04 | — | — | US | disclosed |
| CN-107356742-A | The method that rapid batch detects angiotensin I | 广州金域医学检验中心有限公司 | 2017-11-17 | — | — | CN | disclosed |
| CN-105440348-A | Phosphatized butadiene rubber material and preparation method thereof | HEFEI JIEMING NEW MATERIAL TECH CO LTD | 2016-03-30 | — | — | CN | disclosed |
| EP-1541633-B1 | AQUEOUS SUSPENSION OF CROSSLINKED SILICONE PARTICLES, AQUEOUS EMULSION OF OIL CONTAINING CROSSLINKED SILICONE PARTICLES, AND COSMETIC INGREDIENTS | DOW CORNING TORAY CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| EP-1381651-B1 | POLYORGANOSILOXANE EMULSION COMPOSITION AND A COSMETIC MATERIAL MADE THEREFROM | DOW CORNING TORAY CO LTD (JP) | 2011-06-29 | — | — | EP | disclosed |
| EP-1541633-A1 | AQUEOUS SUSPENSION OF CROSSLINKED SILICONE PARTICLES, AQUEOUS EMULSION OF OIL CONTAINING CROSSLINKED SILICONE PARTICLES, AND COSMETIC INGREDIENTS | Dow Corning Toray Silicone Company, Ltd. (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-20040147647-A1 | Polyorganosiloxane micro-emulsion composition and raw material for cosmetics | DOW CORNING TORAY SILICONE CO., LTD. (JP) | 2004-07-29 | — | — | US | disclosed |
| US-20040138373-A1 | Polyorganosiloxane emulsion composition and a cosmetic material made therefrom | DOW TORAY CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| US-20040091438-A1 | Polyorganosiloxane emulsions,process for producing the same and material for cosmetic preparation | DOW CORNING TORAY SILICONE CO. LTD. (JP) | 2004-05-13 | — | — | US | disclosed |
| EP-1406575-A2 | POLYORGANOSILOXANE MICRO-EMULSION COMPOSITION AND RAW MATERIAL FOR COSMETICS | Dow Corning Toray Silicone Co.,Ltd. Patent Department (JP) | 2004-04-14 | — | — | EP | disclosed |
| EP-1394215-A1 | POLYORGANOSILOXANE EMULSION, PROCESS FOR PRODUCING THE SAME, AND MATERIAL FOR COSMETIC PREPARATION | Dow Corning Toray Silicone Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-1381651-A1 | POLYORGANOSILOXANE EMULSION COMPOSITION AND A COSMETIC MATERIAL MADE THEREFROM | Dow Corning Toray Silicone Co.,Ltd. Patent Department (JP) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002094213-A2 | POLYORGANOSILOXANE MICRO-EMULSION COMPOSITION AND RAW MATERIAL FOR COSMETICS | DOW CORNING TORAY SILICONE CO.,LTD. (JP) | 2002-11-28 | — | — | WO | disclosed |
| WO-2002088253-A1 | POLYORGANOSILOXANE EMULSION COMPOSITION AND A COSMETIC MATERIAL MADE THEREFROM | DOW CORNING TORAY SILICONE CO., LTD. (JP) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040091438-A1 | Polyorganosiloxane emulsions,process for producing the same and material for cosmetic preparation | CUTA, UNG, PCNA | ADRA1A 1150/4885KDR 3530/4885TSHR 4487/4885 |
| US-20040147647-A1 | Polyorganosiloxane micro-emulsion composition and raw material for cosmetics | UNG, PHOSPHO1, TPMT | ADRA1A 1129/4885KDR 3791/4885TSHR 3740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.