SCHEMBL204318

SCHEMBL204318

N=C(N)c1ccc(Br)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.59
▸ PLAU P00749 2/20 0.59
▸ MASP2 O00187 1/20 0.59
▸ THPO P40225 1/20 0.59
▸ PRSS1 P07477 5/20 0.56
▸ PRSS3 P35030 5/20 0.56
▸ F2 P00734 4/20 0.56
▸ APEX1 P27695 1/20 0.56
▸ F10 P00742 2/20 0.55
▸ NQO2 P16083 1/20 0.55
▸ F12 P00748 1/20 0.55
▸ F7 P08709 1/20 0.55
▸ F3 P13726 1/20 0.55
▸ PKM P14618 1/20 0.55
▸ ST14 Q9Y5Y6 3/20 0.54
▸ PRMT5 O14744 1/20 0.54
▸ PRMT1 Q99873 1/20 0.54
▸ ALDH1A1 P00352 1/20 0.54
▸ HPGD P15428 1/20 0.54
▸ CYP2C19 P33261 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL5619195 0.97 LMNA (0.56) LMNAPLAUMASP2THPOPRSS1
Hydrochloric Acid SCHEMBL982825 0.97 PRSS1 (0.61) LMNAPLAUMASP2THPOPRSS1
Hydrochloric Acid SCHEMBL9338860 0.95 LMNA (0.54) LMNAPLAUMASP2THPOPRSS1
SCHEMBL27438192 0.93 WDR5 (0.64) LMNAPLAUMASP2THPOPRSS1
Benzamidine SCHEMBL428760 0.91 F2 (0.73) LMNAPLAUMASP2THPOPRSS1
Hydrochloric Acid SCHEMBL9391856 0.91 WDR5 (0.61) LMNAPLAUMASP2THPOPRSS1
SCHEMBL537030 0.85 LMNA (0.77) LMNAPLAUMASP2THPOPRSS1
Hydrochloric Acid SCHEMBL392375 0.82 PRSS1 (0.78) LMNAPLAUMASP2THPOPRSS1
Hydrochloric Acid SCHEMBL30999366 0.82 PRSS1 (0.78) LMNAPLAUMASP2THPOPRSS1
SCHEMBL32662891 0.77 PLAU (0.64) PLAUPRSS1F2F10F12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 280 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113383039-B Moisture curable polyolefin formulation 陶氏环球技术有限责任公司 2023-09-26 — — CN claimed
US-20220098432-A1 MOISTURE-CURABLE POLYOLEFIN FORMULATION DOW GLOBAL TECHNOLOGIES LLC (US) 2022-03-31 — — US claimed
EP-3924419-A1 MOISTURE-CURABLE POLYOLEFIN FORMULATION Dow Global Technologies LLC (US) 2021-12-22 — — EP claimed
WO-2020164004-A1 MOISTURE-CURABLE POLYOLEFIN FORMULATION DOW GLOBAL TECHNOLOGIES LLC (US) 2020-08-20 — — WO claimed
US-20260109696-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2026-04-23 — — US disclosed
EP-4291183-B1 OXADIAZOLYL DIHYDROPYRANO[2,3-B]PYRIDINE INHIBITORS OF HIPK2 FOR TREATING KIDNEY FIBROSIS ICAHN SCHOOL MED MOUNT SINAI (US) 2026-04-08 — — EP disclosed
US-20260078116-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2026-03-19 — — US disclosed
US-20250179084-A1 OXADIAZOLYL DIHYDROPYRANO[2,3-b]PYRIDINE INHIBITORS OF HIPK2 FOR TREATING KIDNEY FIBROSIS ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2025-06-05 — — US disclosed
EP-4543890-A1 USP1 INHIBITORS AND USES THEREOF Forma Therapeutics, Inc. (US) 2025-04-30 — — EP disclosed
CN-119731178-A USP1 inhibitors and uses thereof 福马治疗有限公司 2025-03-28 — — CN disclosed
US-12043623-B2 Purinones as ubiquitin-specific protease 1 inhibitors FORMA THERAPEUTICS, INC. (US) 2024-07-23 — — US disclosed
US-12043623-B2 Purinones as ubiquitin-specific protease 1 inhibitors FORMA THERAPEUTICS, INC. (US) 2024-07-23 — — US disclosed
WO-1996040117-A1 METHODS OF TREATING MICROBIAL INFECTIONS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1996-12-19 — — WO disclosed
WO-1996040114-A1 METHODS OF INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA AND COMPOUNDS USEFUL THEREFOR THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1996-12-19 — — WO disclosed
US-5521189-A PYRIMIDINE COMPOUNDS AS ANTIPROTOZOA AGENTS THE UNIVERSITY OF NC AT CH (US) 1996-05-28 — — US disclosed
US-4533505-A REACTION OF ETHYLENE IWITH ACID HALIDES IN THE PRESENCE OF A BASE AND A PALLADIUM CATALYST CIBA-GEIGY CORPORATION (US) 1985-08-06 — — US disclosed
EP-0062005-B1 PROCESS FOR THE MANUFACTURE OF STYRENE AND/OR STILBENE DERIVATIVES CIBA-GEIGY AG (CH) 1985-06-26 — — EP disclosed
EP-0062005-A1 Process for the manufacture of styrene and/or stilbene derivatives CIBA-GEIGY AG (CH) 1982-10-06 — — EP disclosed
US-4335055-A Process for the preparation of alkenylbenzene derivatives or alkenylnaphthalene derivatives CIBA-GEIGY CORPORATION (US) 1982-06-15 — — US disclosed
EP-0041043-A1 Process for the preparation of derivatives of alkenyl benzene or alkenyl naphthalene CIBA-GEIGY AG (CH) 1981-12-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179084-A1 OXADIAZOLYL DIHYDROPYRANO[2,3-b]PYRIDINE INHIBITORS OF HIPK2 FOR TREATING KIDNEY FIBROSIS HIPK2, HIPK3, HIPK1 LMNA 4512/4885PLAU 2952/4885MASP2 4564/4885
US-20260078116-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS MYC, KRAS, MCL1 LMNA 2918/4885PLAU 4820/4885MASP2 2886/4885
US-20260109696-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS KRAS, MYC, NRAS LMNA 2258/4885PLAU 4811/4885MASP2 4082/4885
US-12043623-B2 Purinones as ubiquitin-specific protease 1 inhibitors USP1, UBA1, UBXN1 LMNA 2181/4885PLAU 328/4885MASP2 1706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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