Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PLAU | P00749 | 2/20 | 0.54 |
| ▸ | MASP2 | O00187 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.52 |
| ▸ | F2 | P00734 | 4/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.50 |
| ▸ | F10 | P00742 | 2/20 | 0.50 |
| ▸ | C1S | P09871 | 2/20 | 0.50 |
| ▸ | F12 | P00748 | 1/20 | 0.50 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204318 | 0.95 | LMNA (0.59) | LMNAPLAUMASP2THPOPRSS1 | |
| Bromide SCHEMBL5619195 | 0.92 | LMNA (0.56) | LMNAPLAUMASP2THPOPRSS1 | |
| Hydrochloric Acid SCHEMBL982825 | 0.92 | PRSS1 (0.61) | LMNAPLAUMASP2THPOPRSS1 | |
| SCHEMBL27438192 | 0.88 | WDR5 (0.64) | LMNAPLAUMASP2THPOPRSS1 | |
| Hydrochloric Acid SCHEMBL9391856 | 0.86 | WDR5 (0.61) | LMNAPLAUMASP2THPOPRSS1 | |
| Benzamidine SCHEMBL428760 | 0.86 | F2 (0.73) | LMNAPLAUMASP2THPOPRSS1 | |
| SCHEMBL537030 | 0.81 | LMNA (0.77) | LMNAPLAUMASP2THPOPRSS1 | |
| Hydrochloric Acid SCHEMBL30999366 | 0.78 | PRSS1 (0.78) | LMNAPLAUMASP2THPOPRSS1 | |
| Hydrochloric Acid SCHEMBL392375 | 0.78 | PRSS1 (0.78) | LMNAPLAUMASP2THPOPRSS1 | |
| Hydrochloric Acid SCHEMBL29281622 | 0.75 | CES2 (0.56) | LMNAALDH1A1CYP2C19HSD17B10BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0391591-B1 | Pyrimidine derivative and liquid crystal composition incorporating the same | SEIKO EPSON CORP (JP) | 1994-06-15 | — | — | EP | disclosed |
| US-5200110-A | Electro-optical displays; heat resistance, dielectrics, low driving voltage, dielectrics | SEIKO EPSON CORPORATION (JP) | 1993-04-06 | — | — | US | disclosed |
| EP-0391591-A2 | Pyrimidine derivative and liquid crystal composition incorporating the same | SEIKO EPSON CORPORATION (JP) | 1990-10-10 | — | — | EP | disclosed |