Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5952426 | 0.74 | ALDH1A1 (0.59) | LMNAPOLBALDH1A1MAPTHTT | |
| SCHEMBL13180237 | 0.72 | KMT2A (0.50) | LMNAPOLBALDH1A1MAPTHTT | |
| SCHEMBL13374001 | 0.71 | MAPT (0.43) | LMNAPOLBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28797218 | 0.71 | SMN1; SMN2 (0.50) | LMNAALDH1A1HTTSMN1; SMN2CYP1A2 | |
| SCHEMBL11440496 | 0.68 | LMNA (0.46) | LMNAMAPTHTTSMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL4079309 | 0.67 | TAAR1 (0.44) | LMNAALDH1A1MAPTHTTMEN1 | |
| SCHEMBL11447864 | 0.67 | LMNA (0.45) | LMNAALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL14452372 | 0.67 | L3MBTL1 (0.61) | LMNASMN1; SMN2GAA | |
| SCHEMBL13892487 | 0.64 | CNR1 (0.33) | LMNAPOLBALDH1A1MAPTHTT | |
| SCHEMBL4985136 | 0.64 | GABRA1 (0.47) | LMNAPOLBALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935253-B1 | NOVEL HETEROCYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS LTD (CA) | 2018-08-01 | — | — | EP | disclosed |