SCHEMBL20437396

SCHEMBL20437396

CC1(C)c2ccccc2N(c2cc(N3c4ccccc4C(C)(C)c4ccccc43)c(-c3cc(C#N)c(N4c5ccccc5C(C)(C)c5ccccc54)cc3N3c4ccccc4C(C)(C)c4ccccc43)cc2C#N)c2ccccc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 4/20 0.38
KMT2A Q03164 7/20 0.36
MEN1 O00255 6/20 0.36
MAPT P10636 3/20 0.36
HTT P42858 2/20 0.36
CRHBP P24387 1/20 0.36
CRHR2 Q13324 1/20 0.36
KEAP1 Q14145 1/20 0.36
NFE2L2 Q16236 1/20 0.36
CYP1A2 P05177 2/20 0.34
KDM4E B2RXH2 1/20 0.34
CYP2D6 P10635 1/20 0.34
AR P10275 1/20 0.33
USP8 P40818 1/20 0.33
USP7 Q93009 1/20 0.33
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
RAB9A P51151 1/20 0.32
NPSR1 Q6W5P4 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20437401 0.94 PGR (0.38) PGRKMT2AMEN1MAPTHTT
SCHEMBL23958910 0.86 USP8 (0.49) PGRKMT2AMEN1MAPTHTT
SCHEMBL21426911 0.85 CYP1A2 (0.40) PGRKMT2AMEN1CYP1A2KDM4E
SCHEMBL20437392 0.83 PGR (0.39) PGRKMT2AMEN1MAPTHTT
SCHEMBL18411272 0.82 IMPDH2 (0.37) PGRKMT2AMEN1MAPTHTT
SCHEMBL19344985 0.81 PGR (0.43) PGRKMT2AMEN1MAPTHTT
SCHEMBL19345045 0.81 PGR (0.43) PGRKMT2AMEN1MAPTHTT
SCHEMBL17954899 0.80 PGR (0.42) PGRKMT2AMEN1MAPTHTT
SCHEMBL21396769 0.80 PTGER4 (0.33) MAPTKDM4EALDH1A1
SCHEMBL19795553 0.79 PGR (0.44) PGRKMT2AMEN1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180215711-A1 DOPANT FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE SAMSUNG SDI CO., LTD. (KR) 2018-08-02 US disclosed
US-20180215711-A1 DOPANT FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE SAMSUNG SDI CO., LTD. (KR) 2018-08-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180215711-A1 DOPANT FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE OCIAD1, AOX1, AOC2 PGR 4149/4885KMT2A 3423/4885MEN1 2801/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.