SCHEMBL20437403

SCHEMBL20437403

N#Cc1cc(-c2cc(C#N)c(N3c4ccccc4Oc4ccccc43)cc2N2c3ccccc3Oc3ccccc32)c(N2c3ccccc3Oc3ccccc32)cc1N1c2ccccc2Oc2ccccc21

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.36
P2RX4 Q99571 4/20 0.34
USP8 P40818 1/20 0.34
USP7 Q93009 1/20 0.34
LMNA P02545 2/20 0.33
MEN1 O00255 1/20 0.33
CYP1A2 P05177 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C9 P11712 1/20 0.33
MAPK1 P28482 1/20 0.33
CASP1 P29466 1/20 0.33
CYP2C19 P33261 1/20 0.33
HBB P68871 1/20 0.33
KMT2A Q03164 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
MAPKAPK2 P49137 1/20 0.32
IMPDH2 P12268 1/20 0.32
IMPDH1 P20839 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20437411 0.94 MAPT (0.36) KDM4EP2RX4LMNAMEN1CYP1A2
SCHEMBL21425960 0.84 CYP1A2 (0.39) KDM4ELMNAMEN1CYP1A2MAPT
SCHEMBL18196329 0.83 MAPT (0.42) KDM4EP2RX4LMNAMEN1CYP1A2
SCHEMBL20437404 0.82 MAPT (0.36) KDM4EP2RX4LMNAMEN1CYP1A2
SCHEMBL19345079 0.79 CA1 (0.35) KDM4EP2RX4LMNA
SCHEMBL19344958 0.79 KDM4E (0.38) KDM4EP2RX4LMNAMEN1CYP1A2
SCHEMBL17954901 0.79 ESR2 (0.39) KDM4EP2RX4MAPK1
SCHEMBL21397046 0.79 PTGER4 (0.32)
SCHEMBL20437396 0.78 PGR (0.38) KDM4EUSP8USP7LMNAMEN1
SCHEMBL20437413 0.77 MAOA (0.39) KDM4EUSP8USP7MEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180215711-A1 DOPANT FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE SAMSUNG SDI CO., LTD. (KR) 2018-08-02 US disclosed
US-20180215711-A1 DOPANT FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE SAMSUNG SDI CO., LTD. (KR) 2018-08-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180215711-A1 DOPANT FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE OCIAD1, AOX1, AOC2 KDM4E 3869/4885P2RX4 1531/4885USP8 4528/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.