SCHEMBL20437404

SCHEMBL20437404

N#Cc1cc(N2c3ccccc3Oc3ccccc32)c(N2c3ccccc3Oc3ccccc32)cc1-c1cc(N2c3ccccc3Oc3ccccc32)c(N2c3ccccc3Oc3ccccc32)cc1C#N

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.36
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
MAPK1 P28482 1/20 0.36
CASP1 P29466 1/20 0.36
CYP2C19 P33261 1/20 0.36
HBB P68871 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
KDM4E B2RXH2 2/20 0.36
MAPKAPK2 P49137 1/20 0.35
P2RX4 Q99571 4/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
ALDH1A1 P00352 1/20 0.32
TRPA1 O75762 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18196329 0.91 MAPT (0.42) MAPTMEN1LMNACYP1A2CYP2C9
SCHEMBL20437411 0.89 MAPT (0.36) MAPTMEN1LMNACYP1A2CYP2C9
SCHEMBL20437403 0.82 KDM4E (0.36) MAPTMEN1LMNACYP1A2CYP2C9
SCHEMBL19344992 0.81 KDM4E (0.35) MAPTMEN1LMNACYP1A2CYP2C9
SCHEMBL19344959 0.81 KDM4E (0.35) MAPTMEN1LMNACYP1A2CYP2C9
SCHEMBL17954901 0.80 ESR2 (0.39) MAPK1KDM4EP2RX4TRPA1
SCHEMBL20277019 0.80 OPRD1 (0.39) P2RX4
SCHEMBL17949614 0.79 ESR2 (0.38) KDM4EP2RX4TRPA1
SCHEMBL17883162 0.78 CNR1 (0.36) MAPTMEN1LMNACYP1A2CYP2C9
SCHEMBL17952686 0.78 PDK2 (0.39) MAPTMEN1LMNACYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180215711-A1 DOPANT FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE SAMSUNG SDI CO., LTD. (KR) 2018-08-02 US disclosed
US-20180215711-A1 DOPANT FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE SAMSUNG SDI CO., LTD. (KR) 2018-08-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180215711-A1 DOPANT FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE OCIAD1, AOX1, AOC2 MAPT 862/4885MEN1 2801/4885LMNA 4853/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.