Cn-105

SCHEMBL20439448

CC(=O)NC(C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C(C)C

nearest known ligand 0.47

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	SIRT5	Q9NXA8	3/20	0.47

▸	NPY4R	P50391	13/20	0.43

▸	NPY1R	P25929	8/20	0.43

▸	NPY5R	Q15761	8/20	0.43

▸	NPY2R	P49146	5/20	0.43

▸	SIRT2	Q8IXJ6	1/20	0.43

▸	TFPI	P10646	1/20	0.41

▸	TLR2	O60603	1/20	0.41

▸	NMT2	O60551	1/20	0.39

▸	NMT1	P30419	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Cn-105 SCHEMBL16189774	1.00	SIRT5 (0.47)	SIRT5NPY4RNPY1RNPY5RNPY2R
SCHEMBL20439464	0.98	SIRT5 (0.51)	SIRT5NPY4RNPY1RNPY5RNPY2R
SCHEMBL16189767	0.95	TLR2 (0.48)	SIRT5NPY4RNPY1RNPY5RNPY2R
SCHEMBL20439438	0.95	TLR2 (0.48)	SIRT5NPY4RNPY1RNPY5RNPY2R
SCHEMBL20439410	0.94	TLR2 (0.49)	SIRT5NPY4RNPY1RNPY5RNPY2R
SCHEMBL16189773	0.92	SIRT5 (0.43)	SIRT5NPY4RNPY1RNPY5RNPY2R
SCHEMBL20439405	0.92	SIRT5 (0.43)	SIRT5NPY4RNPY1RNPY5RNPY2R
SCHEMBL23879904	0.90	SIRT5 (0.45)	SIRT5NPY4RNPY1RNPY5RNPY2R
SCHEMBL12035273	0.88	SIRT5 (0.44)	SIRT5NPY4RNPY1RNPY5RNPY2R
SCHEMBL16189768	0.87	NMT2 (0.46)	SIRT5SIRT2TFPITLR2NMT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2018140563-A1	USE OF APOE MIMETIC PEPTIDES FOR REDUCING THE LIKELIHOOD OF EPILEPTOGENESIS	DUKE UNIVERSITY (US)	2018-08-02	—	—	WO	disclosed