Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.47 |
| ▸ | NPY4R | P50391 | 13/20 | 0.43 |
| ▸ | NPY1R | P25929 | 8/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.43 |
| ▸ | NPY2R | P49146 | 5/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | TFPI | P10646 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | NMT2 | O60551 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cn-105 SCHEMBL20439448 | 1.00 | SIRT5 (0.47) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL20439464 | 0.98 | SIRT5 (0.51) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL16189767 | 0.95 | TLR2 (0.48) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL20439438 | 0.95 | TLR2 (0.48) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL20439410 | 0.94 | TLR2 (0.49) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL16189773 | 0.92 | SIRT5 (0.43) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL20439405 | 0.92 | SIRT5 (0.43) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL23879904 | 0.90 | SIRT5 (0.45) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL12035273 | 0.88 | SIRT5 (0.44) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL16189768 | 0.87 | NMT2 (0.46) | SIRT5SIRT2TFPITLR2NMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210395342-A1 | PEPTIDE COMPOUNDS FOR SUPPRESSING INFLAMMATION | UNIV DUKE (US) | 2021-12-23 | — | — | US | disclosed |
| US-11136371-B2 | Peptide compounds for suppressing inflammation | DUKE UNIVERSITY (US) | 2021-10-05 | — | — | US | disclosed |
| US-20190194296-A1 | PEPTIDE COMPOUNDS FOR SUPPRESSING INFLAMMATION | UNIV DUKE (US) | 2019-06-27 | — | — | US | disclosed |
| US-10280210-B2 | Peptide compounds for suppressing inflammation | DUKE UNIVERSITY (US) | 2019-05-07 | — | — | US | disclosed |
| WO-2018140563-A1 | USE OF APOE MIMETIC PEPTIDES FOR REDUCING THE LIKELIHOOD OF EPILEPTOGENESIS | DUKE UNIVERSITY (US) | 2018-08-02 | — | — | WO | disclosed |
| US-20160244507-A1 | PEPTIDE COMPOUNDS FOR SUPPRESSING INFLAMMATION | UNIV DUKE (US) | 2016-08-25 | — | — | US | disclosed |
| US-9303063-B2 | Peptide compounds for suppressing inflammation | DUKE UNIVERSITY (US) | 2016-04-05 | — | — | US | disclosed |
| US-20140315823-A1 | PEPTIDE COMPOUNDS FOR SUPPRESSING INFLAMMATION | DUKE UNIVERSITY (US) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10280210-B2 | Peptide compounds for suppressing inflammation | APOB, IAPP, CCL2 | SIRT5 3974/4885NPY4R 722/4885NPY1R 652/4885 |
| US-20210395342-A1 | PEPTIDE COMPOUNDS FOR SUPPRESSING INFLAMMATION | APOB, IAPP, CCL2 | SIRT5 3974/4885NPY4R 722/4885NPY1R 652/4885 |
| US-11136371-B2 | Peptide compounds for suppressing inflammation | APOB, IAPP, CCL2 | SIRT5 3974/4885NPY4R 722/4885NPY1R 652/4885 |
| US-20190194296-A1 | PEPTIDE COMPOUNDS FOR SUPPRESSING INFLAMMATION | APOB, IAPP, CCL2 | SIRT5 3974/4885NPY4R 722/4885NPY1R 652/4885 |
| US-20140315823-A1 | PEPTIDE COMPOUNDS FOR SUPPRESSING INFLAMMATION | APOB, IAPP, CCL2 | SIRT5 3974/4885NPY4R 722/4885NPY1R 652/4885 |
| US-20160244507-A1 | PEPTIDE COMPOUNDS FOR SUPPRESSING INFLAMMATION | APOB, IAPP, CCL2 | SIRT5 3974/4885NPY4R 722/4885NPY1R 652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.