SCHEMBL20439405

CC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)O)C(C)C

nearest known ligand 0.43

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	SIRT5	Q9NXA8	3/20	0.43

▸	SIRT2	Q8IXJ6	1/20	0.43

▸	GNPAT	O15228	2/20	0.41

▸	TFPI	P10646	1/20	0.39

▸	FURIN	P09958	4/20	0.39

▸	NPY4R	P50391	8/20	0.39

▸	NPY1R	P25929	5/20	0.39

▸	NPY2R	P49146	3/20	0.39

▸	NPY5R	Q15761	3/20	0.39

▸	NMT2	O60551	1/20	0.38

▸	NMT1	P30419	1/20	0.38

▸	TASP1	Q9H6P5	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL16189773	1.00	SIRT5 (0.43)	SIRT5SIRT2GNPATTFPIFURIN
SCHEMBL23879904	0.98	SIRT5 (0.45)	SIRT5SIRT2GNPATTFPIFURIN
SCHEMBL16189768	0.95	NMT2 (0.46)	SIRT5SIRT2TFPIFURINNMT2
SCHEMBL20439451	0.94	SIRT6 (0.46)	SIRT5SIRT2TFPIFURINNMT2
SCHEMBL20439409	0.94	NMT1 (0.48)	SIRT5SIRT2TFPIFURINNMT2
Cn-105 SCHEMBL16189774	0.92	SIRT5 (0.47)	SIRT5SIRT2TFPINPY4RNPY1R
Cn-105 SCHEMBL20439448	0.92	SIRT5 (0.47)	SIRT5SIRT2TFPINPY4RNPY1R
SCHEMBL30097932	0.92	SIRT5 (0.47)	SIRT5SIRT2GNPATFURINNPY4R
SCHEMBL20439464	0.90	SIRT5 (0.51)	SIRT5SIRT2TFPINPY4RNPY1R
SCHEMBL29636352	0.90	NOD1 (0.42)	SIRT5SIRT2FURINNPY4RNPY1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2018140563-A1	USE OF APOE MIMETIC PEPTIDES FOR REDUCING THE LIKELIHOOD OF EPILEPTOGENESIS	DUKE UNIVERSITY (US)	2018-08-02	—	—	WO	disclosed