Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | TPH1 | P17752 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23072622 | 0.90 | — | — | |
| SCHEMBL20439550 | 0.89 | P2RX3 (0.31) | P2RX3KDRPDGFRAHTTKMT2A | |
| SCHEMBL23072613 | 0.84 | LMNA (0.35) | ALDH1A1P2RX3KDRPDGFRAKMT2A | |
| SCHEMBL20437176 | 0.82 | PTGS2 (0.39) | PTGS2ALDH1A1P2RX3KDRPDGFRA | |
| SCHEMBL23072688 | 0.74 | KDR (0.35) | P2RX3KDRPDGFRACSF1RPDGFRB | |
| SCHEMBL20422385 | 0.73 | TPH1 (0.37) | TPH1KMT2AL3MBTL1 | |
| SCHEMBL20422383 | 0.73 | TPH1 (0.37) | TPH1KMT2AL3MBTL1 | |
| SCHEMBL20422623 | 0.73 | L3MBTL1 (0.39) | PTGS2ALDH1A1P2RX3KDRPDGFRA | |
| SCHEMBL539169 | 0.72 | PTGS2 (0.45) | PTGS2ALDH1A1P2RX3KDRCSF1R | |
| SCHEMBL539536 | 0.72 | PTGS2 (0.45) | PTGS2ALDH1A1P2RX3KDRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018138293-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-08-02 | — | — | WO | disclosed |