Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | TET3 | O43151 | 1/20 | 0.38 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.38 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20424845 | 0.94 | KDM4E (0.59) | KDM4EAKR1C1ALDH1A1LMNAKMT2A | |
| SCHEMBL349449 | 0.81 | AKR1C1 (0.52) | KDM4EAKR1C1ALDH1A1LMNAKMT2A | |
| SCHEMBL3099738 | 0.79 | KDM4E (0.53) | KDM4EAKR1C1ALDH1A1LMNAKMT2A | |
| SCHEMBL3095655 | 0.79 | MEN1 (0.51) | KDM4EALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL23713517 | 0.78 | ALDH1A1 (0.61) | KDM4EALDH1A1KMT2AMEN1FAAH | |
| Hydrochloric Acid SCHEMBL7002542 | 0.78 | AKR1C1 (0.50) | AKR1C1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL20430370 | 0.77 | FAAH (0.58) | KDM4EAKR1C1ALDH1A1FAAH | |
| SCHEMBL5673170 | 0.75 | SMN1; SMN2 (0.51) | AKR1C1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL20424834 | 0.73 | KDM4E (0.49) | KDM4EALDH1A1FAAH | |
| SCHEMBL327254 | 0.73 | KDM4E (1.00) | KDM4EALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3573972-B1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2026-01-14 | — | — | EP | disclosed |
| US-11077115-B2 | Rorgamma modulators and uses thereof | GENFIT (FR) | 2021-08-03 | — | — | US | disclosed |
| US-11077115-B2 | Rorgamma modulators and uses thereof | GENFIT (FR) | 2021-08-03 | — | — | US | disclosed |
| WO-2018138359-A1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11077115-B2 | Rorgamma modulators and uses thereof | RORB, RORC, RORA | KDM4E 2276/4885AKR1C1 1520/4885ALDH1A1 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.