Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5572597 | 0.78 | LMNA (0.55) | SMN1; SMN2LMNAALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL349449 | 0.77 | AKR1C1 (0.52) | SMN1; SMN2LMNAALDH1A1AKR1C1CYP3A4 | |
| SCHEMBL20439648 | 0.75 | KDM4E (0.56) | SMN1; SMN2LMNAALDH1A1AKR1C1MEN1 | |
| Hydrochloric Acid SCHEMBL7002542 | 0.74 | AKR1C1 (0.50) | SMN1; SMN2LMNAALDH1A1AKR1C1CYP3A4 | |
| SCHEMBL17737077 | 0.73 | KMO (0.57) | SMN1; SMN2ALDH1A1MEN1KMT2APKM | |
| SCHEMBL3097606 | 0.72 | TSHR (0.58) | SMN1; SMN2ALDH1A1CYP3A4CYP2C19MEN1 | |
| SCHEMBL20424845 | 0.72 | KDM4E (0.59) | LMNAALDH1A1AKR1C1MEN1KMT2A | |
| SCHEMBL13271405 | 0.70 | ALDH1A1 (0.53) | SMN1; SMN2LMNAALDH1A1CYP2C19MEN1 | |
| SCHEMBL9023593 | 0.69 | AKR1C1 (0.70) | SMN1; SMN2AKR1C1CYP3A4CYP2C19MEN1 | |
| SCHEMBL14982126 | 0.69 | GSK3B (0.53) | SMN1; SMN2LMNAALDH1A1PKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276748-B1 | 13-SUBSTITUTED MILBEMYCIN DERIVATIVES, THEIR PREPARATION AND THEIR USE AGAINST INSECTS AND OTHER PESTS | SANKYO LIFETECH COMPANY LTD (JP) | 2006-01-11 | — | — | EP | disclosed |
| US-6653342-B2 | Acaricidal, insecticidal and anthelmintic activity on plants and animals; such as 13-(1-(4-aminophenyl)cyclopentane-carbonyloxy)-5-hydroxymilbemycin A4 | SANKYO COMPANY, LIMITED (JP) | 2003-11-25 | — | — | US | disclosed |
| US-20030139601-A1 | 13-substituted milbemycin derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY, LIMITED (JP) | 2003-07-24 | — | — | US | disclosed |
| EP-1276748-A1 | 13-SUBSTITUTED MILBEMYCIN DERIVATIVES, THEIR PREPARATION AND THEIR USE AGAINST INSECTS AND OTHER PESTS | Sankyo Company, Limited (JP) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001083500-A1 | 13-SUBSTITUTED MILBEMYCIN DERIVATIVES, THEIR PREPARATION AND THEIR USE AGAINST INSECTS AND OTHER PESTS | SANKYO COMPANY, LIMITED (JP) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139601-A1 | 13-substituted milbemycin derivatives, their preparation and their use against insects and other pests | MRM1, CYCS, RPS27 | SMN1; SMN2 2713/4885LMNA 1008/4885ALDH1A1 1043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.