Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | NAMPT | P43490 | 3/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.52 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.52 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27952268 | 0.78 | LMNA (0.70) | LMNAMAPK1NAMPTBCHERAB9A | |
| SCHEMBL9302673 | 0.76 | MAPK14 (0.75) | LMNASMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL20445449 | 0.75 | NPC1 (0.65) | LMNANAMPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2076281 | 0.75 | HPSE (0.72) | NR1H4RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL28909751 | 0.74 | NPC1 (0.69) | LMNANAMPTRAB9ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2104423 | 0.74 | NR1H4 (0.70) | NR1H4RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7610512 | 0.73 | L3MBTL1 (0.61) | LMNAMAPK1NR1H4MEN1KMT2A | |
| SCHEMBL23513412 | 0.73 | NPC1 (0.74) | MAPK1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL259468 | 0.73 | KCNK3 (0.87) | LMNAMAPK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29434800 | 0.73 | KCNK3 (0.87) | LMNAMAPK1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018140504-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | PATEL MANOJ K (US) | 2018-08-02 | — | — | WO | disclosed |