Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.61 |
| ▸ | RAB9A | P51151 | 9/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3335064 | 0.84 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2MEN1POLB | |
| SCHEMBL35046 | 0.81 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2MEN1POLB | |
| SCHEMBL8957841 | 0.80 | RAB9A (0.71) | NPC1RAB9ASMN1; SMN2MEN1POLB | |
| SCHEMBL12999376 | 0.79 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2MEN1POLB | |
| SCHEMBL34865 | 0.79 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2MEN1POLB | |
| SCHEMBL14665558 | 0.77 | NPC1 (0.79) | NPC1RAB9ASMN1; SMN2MEN1POLB | |
| SCHEMBL26293782 | 0.77 | NPBWR1 (0.56) | NPC1RAB9ASMN1; SMN2MEN1POLB | |
| SCHEMBL14665681 | 0.76 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MEN1POLB | |
| SCHEMBL14665614 | 0.76 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MEN1POLB | |
| SCHEMBL5595394 | 0.76 | MEN1 (0.72) | NPC1RAB9ASMN1; SMN2MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018140504-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | PATEL MANOJ K (US) | 2018-08-02 | — | — | WO | disclosed |