SCHEMBL2046979

SCHEMBL2046979

NSc1nc2c(S)cccc2s1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSMD14 O00487 2/20 0.36
COPS5 Q92905 2/20 0.36
ALDH1A1 P00352 8/20 0.36
LMNA P02545 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
PDPK1 O15530 1/20 0.36
PDE10A Q9Y233 1/20 0.36
TDP1 Q9NUW8 4/20 0.35
HPGD P15428 3/20 0.35
FBP1 P09467 2/20 0.35
ADRA2A P08913 1/20 0.35
ADORA3 P0DMS8 1/20 0.35
DRD2 P14416 1/20 0.35
ALOX15 P16050 1/20 0.35
ADRA2B P18089 1/20 0.35
ADRA2C P18825 1/20 0.35
DRD1 P21728 1/20 0.35
MC5R P33032 1/20 0.35
OPRM1 P35372 1/20 0.35
DRD3 P35462 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29539652 1.00 PSMD14 (0.36) PSMD14COPS5ALDH1A1LMNASMN1; SMN2
SCHEMBL1563617 0.85 PSMD14 (0.38) PSMD14COPS5ALDH1A1LMNASMN1; SMN2
SCHEMBL83283 0.85 ALDH1A1 (0.50) PSMD14COPS5ALDH1A1LMNASMN1; SMN2
Morpholine SCHEMBL9244682 0.85 SMN1; SMN2 (0.35) ALDH1A1LMNASMN1; SMN2HPGDALOX15
SCHEMBL83284 0.84 PSMD14 (0.37) PSMD14COPS5ALDH1A1LMNASMN1; SMN2
SCHEMBL7754418 0.82 ALDH1A1 (0.37) PSMD14COPS5ALDH1A1LMNASMN1; SMN2
SCHEMBL27791854 0.82 SMN1; SMN2 (0.44) PSMD14COPS5ALDH1A1SMN1; SMN2TDP1
SCHEMBL29515259 0.79 ALDH1A1 (0.61) ALDH1A1LMNASMN1; SMN2TDP1HPGD
SCHEMBL9193542 0.78 ALDH1A1 (0.37) ALDH1A1LMNASMN1; SMN2PDPK1PDE10A
SCHEMBL4443518 0.76 ALDH1A1 (0.31) ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040122181-A1 Vulcanization accelerators GREAT LAKES CHEMICAL ITALIA S.R.L. (IT) 2004-06-24 US claimed
US-6281295-B1 Enamines as vulcanization accelerators for natural or synthetic rubbers GREAT LAKES CHEMICAL ITALIA S.R.L. (IT) 2001-08-28 US claimed
US-6184296-B1 SUITABLE FOR PRODUCTION OF LOW ROLLING RESISTANCE MOTOR VEHICLE TIRE TREADS BAYER AG (DE) 2001-02-06 US claimed
EP-0735083-B1 Enamines as vulcanization accelerators for natural or synthetic rubbers GREAT LAKES CHEMICAL EUROP (CH) 2000-02-09 EP claimed
EP-0634448-B1 Use of enamines as vulcanization accelerators GREAT LAKES CHEMICAL ITALIA (IT) 1999-09-22 EP claimed
US-5747601-A Dihydropyridines as vulcanization accelerators for natural or synthetic rubbers GREAT LAKES CHEMICAL ITALIA S.R.L. (IT) 1998-05-05 US claimed
EP-0794219-A1 Dihydropyridines as vulcanization accelerators for natural or synthetic rubbers GREAT LAKES CHEMICAL ITALIA S.r.l. (IT) 1997-09-10 EP claimed
EP-0735083-A1 Enamines as vulcanization accelerators for natural or synthetic rubbers GREAT LAKES CHEMICAL ITALIA S.r.l. (IT) 1996-10-02 EP claimed
EP-0634448-A1 Vulcanization accelerators GREAT LAKES CHEMICAL ITALIA S.r.l. (IT) 1995-01-18 EP claimed
US-20260109789-A1 DEVULCANIZED RUBBER, PROCESS FOR PRODUCING DEVULCANIZED RUBBER, AND USE THEREOF EVONIK OPERATIONS GMBH (DE) 2026-04-23 US disclosed
WO-2025202158-A1 DEVULCANIZED RUBBER AND PROCESS FOR PRODUCING THEREOF EVONIK OPERATIONS GMBH (DE) 2025-10-02 WO disclosed
EP-4433532-B1 DEVULCANIZED RUBBER, PROCESS FOR PRODUCING DEVULCANIZED RUBBER, AND USE THEREOF EVONIK OPERATIONS GMBH (DE) 2025-04-02 EP disclosed
EP-4433532-A1 DEVULCANIZED RUBBER, PROCESS FOR PRODUCING DEVULCANIZED RUBBER, AND USE THEREOF Evonik Operations GmbH (DE) 2024-09-25 EP disclosed
US-20240174840-A1 USE OF A STABILIZER COMPOSITION FOR STABILIZING ORGANIC MATERIALS, STABILIZER COMPOSITION, MASTER BATCH, COMPOSITION, MOLDING COMPOUND FOR MOLDINGS, PROCESS FOR OXIDATIVE, THERMAL AND ACTINIC STABILIZATION OF A THERMOPLASTIC, AND USE OF A COMPOSITION Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2024-05-30 US disclosed
WO-1992001628-A1 CARBON BLACK AND RUBBER COMPOSITION CONTAINING SAME CABOT CORPORATION (US) 1992-02-06 WO disclosed
WO-1991017114-A1 CARBON BLACK AND RUBBER COMPOSITION CONTAINING SAME CABOT CORPORATION (US) 1991-11-14 WO disclosed
EP-0120833-B1 RUBBER MIXTURE FOR THE INNER TUBES OF PNEUMATIC TYRES Semperit Reifen Aktiengesellschaft (AT) 1986-11-12 EP disclosed
EP-0120833-A1 Rubber mixture for the inner tubes of pneumatic tyres Semperit Reifen Aktiengesellschaft (AT) 1984-10-03 EP disclosed
US-4000119-A HERBICIDE, RUBBER AIDS DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) 1976-12-28 US disclosed
US-3969353-A HERBICIDES, RUBBER ADDITIVES DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) 1976-07-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040122181-A1 Vulcanization accelerators ERCC2, DNMT3A, OGG1 PSMD14 678/4885COPS5 972/4885ALDH1A1 2914/4885
US-20260109789-A1 DEVULCANIZED RUBBER, PROCESS FOR PRODUCING DEVULCANIZED RUBBER, AND USE THEREOF SRMS, VCL, TST PSMD14 134/4885COPS5 1151/4885ALDH1A1 2660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.