Cyclohexane Carboxamide

Cyclohexane Carboxamide

SCHEMBL204775

NC(=O)C1CCCCC1.O=S1(=O)C=Cc2ccccc21

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 1/20 0.38
GRM4 Q14833 1/20 0.38
KMT2A Q03164 2/20 0.37
ALDH1A1 P00352 3/20 0.37
CYP2C19 P33261 2/20 0.37
BRCA1 P38398 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
HPGD P15428 1/20 0.36
HDAC3 O15379 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC2 Q92769 1/20 0.35
LMNA P02545 1/20 0.35
JAK2 O60674 1/20 0.35
JAK1 P23458 1/20 0.35
PLCG2 P16885 1/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA9 Q16790 2/20 0.34
KDM4E B2RXH2 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31003510 0.76 CA9 (0.46) KMT2ALMNAPLCG2CA1CA2
SCHEMBL62430 0.76 CA9 (0.46) KMT2ALMNAPLCG2CA1CA2
Methoxymethane SCHEMBL10856175 0.69 CA9 (0.41) KMT2APLCG2CA1CA2CA9
Cyclohexane Carboxamide SCHEMBL694153 0.69 PTPN1 (0.55) SIRT2KMT2AALDH1A1HPGDHDAC3
Phthalic Acid SCHEMBL30731306 0.68 ALDH1A1 (0.52) SIRT2KMT2AALDH1A1HPGDHDAC3
Phthalic Acid SCHEMBL27812813 0.68 ALDH1A1 (0.52) SIRT2KMT2AALDH1A1HPGDHDAC3
SCHEMBL25485911 0.68 CES2 (0.58) KMT2AALDH1A1LMNAKDM4ESMN1; SMN2
Cyclohexane Carboxamide SCHEMBL26181 0.68
SCHEMBL217428 0.68 CES2 (0.58) KMT2AALDH1A1LMNAKDM4ESMN1; SMN2
SCHEMBL218387 0.68 CES2 (0.58) KMT2AALDH1A1LMNAKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 238 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1412426-B1 MILDEW-RESISTANT SEALING COMPOUND FORMULATIONS CONTAINING A BENZOTHIOPHENE-2-CYCLOHEXYLCARBOXAMIDE-S,S-DIOXIDE GE BAYER SILICONES GMBH & CO (DE) 2007-06-13 EP claimed
US-20050003205-A1 Mildew-resistant sealing compound formulations containing a benzothiophene-2-cy-clohexylcarboxamide-s,s-dioxide GE BAYER SILICONES GMBH & CO. KG (DE) 2005-01-06 US claimed
EP-3746505-B1 COMPOSITION, POLYMER COMPOSITE ARTICLE FORMED THEREWITH, AND METHOD OF PREPARING SAME DOW SILICONES CORP (US) 2024-06-26 EP disclosed
EP-3906245-B1 MULTIFUNCTIONAL ORGANOSILICON COMPOUND AND RELATED METHODS, COMPOUNDS, AND COMPOSITIONS DOW SILICONES CORP (US) 2024-05-29 EP disclosed
US-20240124709-A1 COMPOSITION, POLYMER COMPOSITE ARTICLE FORMED THEREWITH, AND METHOD OF PREPARING SAME DOW GLOBAL TECHNOLOGIES LLC 2024-04-18 US disclosed
EP-3645640-B1 SILICONE-POLYETHER COPOLYMER, METHOD OF PREPARING SAME, AND SEALANT COMPRISING SAME DOW SILICONES CORP (US) 2024-03-06 EP disclosed
US-11884821-B2 Composition, polymer composite article formed therewith, and method of preparing same DOW SILICONES CORPORATION (US) 2024-01-30 US disclosed
US-11820846-B2 Composition, method of preparing copolymer, and methods and end uses thereof DOW SILICONES CORPORATION (US) 2023-11-21 US disclosed
WO-2023215360-A1 SILICONE-POLYETHER COPOLYMER, SEALANTS COMPRISING SAME, AND RELATED METHODS DOW SILICONES CORPORATION (US) 2023-11-09 WO disclosed
US-11807775-B2 Silicone-organic copolymer, sealants comprising same, and related methods DOW SILICONES CORPORATION (US) 2023-11-07 US disclosed
US-11760841-B2 Silicone-polycarbonate copolymer, sealants comprising same, and related methods DOW SILICONES CORPORATION (US) 2023-09-19 US disclosed
WO-2006107762-A1 ORGANOSILOXANE COMPOSITIONS DOW CORNING CORPORATION (US) 2006-10-12 WO disclosed
US-20060142359-A1 Cyclopenta[c]isoxazole-3-amines used as protective agents for materials LANXESS DEUTSCHLAND GMBH (DE) 2006-06-29 US disclosed
US-20060142384-A1 2-Oxyamino-1-cyclopentene-1-nitriles as material protective agents LANXESS DEUTSCHLAND GMBH (DE) 2006-06-29 US disclosed
US-20060089352-A1 Substituted thiazines as material protecting agents LANXESS DEUTSCHLAND GMBH (DE) 2006-04-27 US disclosed
US-20050003205-A1 Mildew-resistant sealing compound formulations containing a benzothiophene-2-cy-clohexylcarboxamide-s,s-dioxide GE BAYER SILICONES GMBH & CO. KG (DE) 2005-01-06 US disclosed
US-20050003205-A1 Mildew-resistant sealing compound formulations containing a benzothiophene-2-cy-clohexylcarboxamide-s,s-dioxide GE BAYER SILICONES GMBH & CO. KG (DE) 2005-01-06 US disclosed
EP-1412426-A2 MILDEW-RESISTANT SEALING COMPOUND FORMULATIONS CONTAINING A BENZOTHIOPHENE-2-CYCLOHEXYLCARBOXAMIDE-S,S-DIOXIDE GE Bayer Silicones GmbH & Co. KG (DE) 2004-04-28 EP disclosed
WO-2003006543-A3 MILDEW-RESISTANT SEALING COMPOUND FORMULATIONS CONTAINING A BENZOTHIOPHENE-2-CYCLOHEXYLCARBOXAMIDE-S,S-DIOXIDE GE BAYER SILICONES GMBH & CO (DE) 2003-05-01 WO disclosed
WO-2003006543-A2 MILDEW-RESISTANT SEALING COMPOUND FORMULATIONS CONTAINING A BENZOTHIOPHENE-2-CYCLOHEXYLCARBOXAMIDE-S,S-DIOXIDE GE BAYER SILICONES GMBH & CO. KG (DE) 2003-01-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11820846-B2 Composition, method of preparing copolymer, and methods and end uses thereof BRS3, OXSR1, OXER1 SIRT2 3758/4885GRM4 1708/4885KMT2A 4700/4885
US-20060142384-A1 2-Oxyamino-1-cyclopentene-1-nitriles as material protective agents NOS1, CBR1, NOS2 SIRT2 3077/4885GRM4 4478/4885KMT2A 4069/4885
US-20060089352-A1 Substituted thiazines as material protecting agents POT1, TST, MIF SIRT2 2484/4885GRM4 3153/4885KMT2A 3155/4885
US-20060142359-A1 Cyclopenta[c]isoxazole-3-amines used as protective agents for materials NOS1, CYC1, CAT SIRT2 2812/4885GRM4 4208/4885KMT2A 4172/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.