Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20482266 | 0.90 | PPARA (0.36) | KDM4EALDH1A1MAPTREN | |
| SCHEMBL4504503 | 0.81 | HSD11B1 (0.41) | KDM4EHDAC8ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL20482542 | 0.80 | ITGB1 (0.41) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL20482686 | 0.80 | ITGB1 (0.39) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL20482538 | 0.79 | KDM4E (0.33) | KDM4EALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL20482551 | 0.78 | KMT2A (0.49) | KDM4EALDH1A1MAPTNPC1LMNA | |
| SCHEMBL20482522 | 0.78 | REN (0.44) | ALDH1A1REN | |
| SCHEMBL16929923 | 0.74 | CA2 (0.38) | KDM4EHDAC8ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL20482549 | 0.72 | REN (0.44) | ALDH1A1MEN1KMT2AREN | |
| SCHEMBL8285816 | 0.72 | ALDH1A1 (0.43) | KDM4EHDAC8ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018154466-A1 | DIHYDROQUINOLIZINONES AS ANTIVIRALS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-08-30 | — | — | WO | disclosed |