Sugi Predict

Sugi Predict / Compounds / SCHEMBL20501022

SCHEMBL20501022

SCHEMBL20501022

CCCc1ccc(NC(=O)Nc2cccc(-c3cnc(N)[nH]3)c2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SCN9A Q15858 2/20 0.50
▸ SCN4A P35499 1/20 0.50
▸ SCN3A Q9NY46 1/20 0.50
▸ ABCG2 Q9UNQ0 2/20 0.45
▸ MEN1 O00255 2/20 0.45
▸ NPC1 O15118 2/20 0.45
▸ RAB9A P51151 2/20 0.45
▸ KMT2A Q03164 2/20 0.45
▸ CASP3 P42574 1/20 0.45
▸ SENP8 Q96LD8 1/20 0.45
▸ SENP7 Q9BQF6 1/20 0.45
▸ SENP6 Q9GZR1 1/20 0.45
▸ AOC3 Q16853 1/20 0.43
▸ NTRK1 P04629 2/20 0.42
▸ NTRK2 Q16620 2/20 0.42
▸ CNR1 P21554 2/20 0.42
▸ CDK8 P49336 1/20 0.42
▸ UBE2N P61088 1/20 0.42
▸ PAX8 Q06710 1/20 0.42
▸ LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20500986 0.94 MEN1 (0.54) SCN9ASCN4ASCN3AMEN1NPC1
SCHEMBL20501115 0.91 SCN9A (0.52) SCN9ASCN4ASCN3AMEN1NPC1
SCHEMBL24176659 0.87 SCN9A (0.48) SCN9ASCN4ASCN3AMEN1KMT2A
SCHEMBL20501157 0.86 SCN9A (0.57) SCN9ASCN4ASCN3ACNR1KDR
SCHEMBL20501030 0.86 SCN9A (0.61) SCN9ASCN4ASCN3ANTRK1NTRK2
SCHEMBL20501098 0.86 SCN9A (0.53) SCN9ASCN4ASCN3ACNR1LMNA
SCHEMBL20501039 0.85 KDR (0.54) SCN9ASCN4ASCN3ANPC1RAB9A
SCHEMBL20501076 0.85 SCN9A (0.61) SCN9ASCN4ASCN3AMEN1NPC1
SCHEMBL20501033 0.85 RAB9A (0.56) SCN9ASCN4ASCN3AMEN1NPC1
SCHEMBL20501013 0.83 CNR1 (0.61) SCN9ASCN4ASCN3ACNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11582970-B2 2-aminoimidazole-phenyl derivatives useful for controlling microbial growth NORTH CAROLINA STATE UNIVERSITY (US) 2023-02-21 — — US disclosed
US-20220000118-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-01-06 — — US disclosed
CN-110740645-A 2-aminoimidazole-phenyl derivatives for controlling microbial growth 北卡罗莱纳州立大学 2020-01-31 — — CN disclosed
WO-2018169752-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH NORTH CAROLINA STATE UNIVERSITY (US) 2018-09-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11582970-B2 2-aminoimidazole-phenyl derivatives useful for controlling microbial growth DDC, IL4I1, ING2 SCN9A 4811/4885SCN4A 4688/4885SCN3A 4795/4885
US-20220000118-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH DDC, IL4I1, ING2 SCN9A 4811/4885SCN4A 4688/4885SCN3A 4795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.