Sugi Predict

Sugi Predict / Compounds / SCHEMBL20501033

SCHEMBL20501033

SCHEMBL20501033

CCOc1ccc(NC(=O)Nc2cccc(-c3cnc(N)[nH]3)c2)cc1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 8/20 0.56
▸ NPC1 O15118 6/20 0.56
▸ SMN1; SMN2 Q16637 4/20 0.56
▸ MITF O75030 1/20 0.56
▸ PAX8 Q06710 1/20 0.56
▸ MAPT P10636 11/20 0.54
▸ PKM P14618 2/20 0.54
▸ MEN1 O00255 6/20 0.54
▸ KMT2A Q03164 6/20 0.54
▸ POLB P06746 2/20 0.51
▸ SCN4A P35499 1/20 0.50
▸ SCN9A Q15858 1/20 0.50
▸ SCN3A Q9NY46 1/20 0.50
▸ GBA1 P04062 1/20 0.49
▸ TP53 P04637 1/20 0.49
▸ LMNA P02545 1/20 0.49
▸ KDM4E B2RXH2 2/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20501115 0.87 SCN9A (0.52) RAB9ANPC1SMN1; SMN2PAX8MAPT
SCHEMBL20501157 0.86 SCN9A (0.57) SCN4ASCN9ASCN3A
SCHEMBL20501030 0.86 SCN9A (0.61) MAPTSCN4ASCN9ASCN3ATP53
SCHEMBL20500945 0.86 RORC (0.51) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL20501039 0.85 KDR (0.54) RAB9ANPC1SMN1; SMN2MAPTPOLB
SCHEMBL20501076 0.85 SCN9A (0.61) RAB9ANPC1MAPTMEN1KMT2A
SCHEMBL20501022 0.85 SCN9A (0.50) RAB9ANPC1SMN1; SMN2PAX8MAPT
SCHEMBL20500975 0.84 MAPT (0.54) RAB9ANPC1MAPTMEN1KMT2A
SCHEMBL20501013 0.83 CNR1 (0.61) SCN4ASCN9ASCN3A
SCHEMBL20500996 0.82 SCN9A (0.53) RAB9ANPC1SMN1; SMN2MAPTSCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11582970-B2 2-aminoimidazole-phenyl derivatives useful for controlling microbial growth NORTH CAROLINA STATE UNIVERSITY (US) 2023-02-21 — — US disclosed
US-20220000118-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-01-06 — — US disclosed
CN-110740645-A 2-aminoimidazole-phenyl derivatives for controlling microbial growth 北卡罗莱纳州立大学 2020-01-31 — — CN disclosed
WO-2018169752-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH NORTH CAROLINA STATE UNIVERSITY (US) 2018-09-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11582970-B2 2-aminoimidazole-phenyl derivatives useful for controlling microbial growth DDC, IL4I1, ING2 RAB9A 3935/4885NPC1 4159/4885SMN1; SMN2 4611/4885
US-20220000118-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH DDC, IL4I1, ING2 RAB9A 3935/4885NPC1 4159/4885SMN1; SMN2 4611/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.