Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20512227 | 0.93 | ALDH1A1 (0.50) | ALDH1A1CA12CA2CA9MEN1 | |
| SCHEMBL20512229 | 0.84 | ALDH1A1 (0.53) | ALDH1A1CA12CA9MEN1KMT2A | |
| SCHEMBL20512261 | 0.81 | CA12 (0.52) | ALDH1A1CA12CA2CA9MEN1 | |
| SCHEMBL20512265 | 0.81 | ALDH1A1 (0.50) | ALDH1A1CA12CA2CA9MEN1 | |
| SCHEMBL20512258 | 0.79 | NPSR1 (0.51) | ALDH1A1CA12CA9MEN1KMT2A | |
| SCHEMBL20512264 | 0.78 | RAB9A (0.53) | ALDH1A1CA12CA9MEN1KMT2A | |
| SCHEMBL20512253 | 0.77 | ALDH1A1 (0.51) | ALDH1A1CA2MEN1KMT2ALMNA | |
| SCHEMBL20512270 | 0.76 | ALDH1A1 (0.55) | ALDH1A1CA12CA2CA9MEN1 | |
| SCHEMBL187922 | 0.74 | ALDH1A1 (0.72) | ALDH1A1CA12CA2CA9MEN1 | |
| SCHEMBL634316 | 0.74 | ALDH1A1 (0.71) | ALDH1A1CA12CA2CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180354963-A1 | NOVEL LACTONES | PURDUE RESEARCH FOUNDATION (US) | 2018-12-13 | — | — | US | disclosed |
| US-10138252-B1 | Lactones | PURDUE RESEARCH FOUNDATION (US) | 2018-11-27 | — | — | US | disclosed |
| US-20180305371-A1 | NOVEL LACTONES | PURDUE RESEARCH FOUNDATION (US) | 2018-10-25 | — | — | US | disclosed |
| US-10087190-B1 | Lactones | PURDUE RESEARCH FOUNDATION (US) | 2018-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180354963-A1 | NOVEL LACTONES | DHPS, FDPS, LSS | ALDH1A1 2443/4885CA12 1994/4885CA2 3221/4885 |
| US-20180305371-A1 | NOVEL LACTONES | DHPS, FDPS, LSS | ALDH1A1 2443/4885CA12 1994/4885CA2 3221/4885 |
| US-10138252-B1 | Lactones | DHPS, FDPS, LSS | ALDH1A1 2208/4885CA12 1883/4885CA2 2868/4885 |
| US-10087190-B1 | Lactones | DHPS, FDPS, LSS | ALDH1A1 2208/4885CA12 1883/4885CA2 2868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.