SCHEMBL20522305

SCHEMBL20522305

Nc1ncc(C2CCN(S(=O)(=O)c3ccc(F)cc3)CC2)s1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR2B P41595 1/20 0.52
▸ KMT2A Q03164 2/20 0.48
▸ HDAC3 O15379 1/20 0.47
▸ HDAC4 P56524 1/20 0.47
▸ HDAC1 Q13547 1/20 0.47
▸ HDAC7 Q8WUI4 1/20 0.47
▸ HDAC2 Q92769 1/20 0.47
▸ HDAC10 Q969S8 1/20 0.47
▸ HDAC11 Q96DB2 1/20 0.47
▸ HDAC8 Q9BY41 1/20 0.47
▸ HDAC6 Q9UBN7 1/20 0.47
▸ HDAC9 Q9UKV0 1/20 0.47
▸ HDAC5 Q9UQL6 1/20 0.47
▸ PKM P14618 2/20 0.47
▸ L3MBTL1 Q9Y468 2/20 0.46
▸ USP5 P45974 1/20 0.46
▸ KDM4E B2RXH2 3/20 0.45
▸ GAA P10253 1/20 0.44
▸ LMNA P02545 2/20 0.44
▸ TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20522400 0.80 HTR2B (0.49) HTR2BKMT2APKML3MBTL1KDM4E
SCHEMBL20522364 0.78 KMT2A (0.54) HTR2BKMT2AHDAC3HDAC4HDAC1
SCHEMBL28323085 0.76 HTR2B (0.50) HTR2BKMT2APKML3MBTL1USP5
SCHEMBL2060095 0.73 PKM (0.62) KMT2APKML3MBTL1KDM4EGAA
SCHEMBL1711115 0.71 PKM (0.85) KMT2APKML3MBTL1KDM4ELMNA
SCHEMBL266490 0.70 MEN1 (0.75) KMT2APKML3MBTL1KDM4ELMNA
SCHEMBL22736908 0.70 HTR7 (0.49) L3MBTL1KDM4EHTR2ARAB9A
SCHEMBL342315 0.69 — —
SCHEMBL15244548 0.69 NOS1 (0.39) GAA
SCHEMBL13521268 0.69 NOS1 (0.35) GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12384772-B2 Inhibitors VIVORYON THERAPEUTICS N.V. (DE) 2025-08-12 — — US claimed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 — — US claimed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 — — EP claimed
CN-110719910-A Novel inhibitors 前体生物药物股份公司 2020-01-21 — — CN claimed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 — — WO claimed
US-20260001873-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2026-01-01 — — US disclosed
US-12384772-B2 Inhibitors VIVORYON THERAPEUTICS N.V. (DE) 2025-08-12 — — US disclosed
CN-117024352-A Novel inhibitors 维沃里翁治疗股份有限公司 2023-11-10 — — CN disclosed
CN-110719910-B Novel inhibitors 维沃里翁治疗股份有限公司 2023-07-21 — — CN disclosed
US-20220274977-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2022-09-01 — — US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 — — US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 — — US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 — — US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 — — US disclosed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 — — EP disclosed
CN-110719910-A Novel inhibitors 前体生物药物股份公司 2020-01-21 — — CN disclosed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260001873-A1 NOVEL INHIBITORS GLS, GLS2, SULT1E1 HTR2B 1636/4885KMT2A 3101/4885HDAC3 1530/4885
US-20200377493-A1 NOVEL INHIBITORS GLUL, GLS, QPCT HTR2B 2259/4885KMT2A 2829/4885HDAC3 2664/4885
US-11339152-B2 Inhibitors GLUL, QPCT, GLS HTR2B 2419/4885KMT2A 2908/4885HDAC3 2945/4885
US-12384772-B2 Inhibitors GLS, QPCT, GLS2 HTR2B 1604/4885KMT2A 2772/4885HDAC3 3350/4885
US-20220274977-A1 NOVEL INHIBITORS GLUL, GLS, QPCT HTR2B 2490/4885KMT2A 2867/4885HDAC3 2819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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