Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBBP9 | O75884 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669020 | 0.81 | ALDH1A1 (0.40) | RBBP9PLA2G4AALDH1A1CES1PLA2G7 | |
| SCHEMBL8866092 | 0.81 | ALDH1A1 (0.54) | RBBP9NPC1RAB9APLA2G4AALDH1A1 | |
| SCHEMBL6154147 | 0.78 | RBBP9 (0.49) | RBBP9NPC1RAB9APLA2G4AALDH1A1 | |
| SCHEMBL17627808 | 0.78 | LMNA (0.49) | RBBP9NPC1RAB9APLA2G4AALDH1A1 | |
| SCHEMBL9408186 | 0.78 | PLA2G4A (0.38) | RBBP9NPC1RAB9APLA2G4AALDH1A1 | |
| SCHEMBL6154144 | 0.77 | RBBP9 (0.48) | RBBP9NPC1RAB9APLA2G4AALDH1A1 | |
| SCHEMBL2008703 | 0.77 | PLA2G7 (0.57) | RBBP9NPC1RAB9APLA2G4AALDH1A1 | |
| SCHEMBL6142537 | 0.77 | ALDH1A1 (0.39) | RBBP9NPC1RAB9APLA2G4AALDH1A1 | |
| Bromide SCHEMBL27504054 | 0.76 | PLA2G7 (0.56) | RBBP9NPC1RAB9APLA2G4AALDH1A1 | |
| SCHEMBL16850633 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486289-B2 | Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof | THE BROAD INSTITUTE, INC. (US) | 2025-12-02 | — | — | US | disclosed |
| EP-3606528-B1 | TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF | BROAD INST INC (US) | 2023-10-18 | — | — | EP | disclosed |
| CN-110958882-B | Tricyclic compounds as glycogen synthase kinase 3 (GSK 3) inhibitors and uses thereof | 布罗德研究所股份有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-113248422-B | Chiral alpha-aza-arene quaternary carbon center compound, and preparation method and application thereof | 河南工业大学 | 2022-07-12 | — | — | CN | disclosed |
| US-20220112216-A1 | TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-04-14 | — | — | US | disclosed |
| US-11203601-B2 | Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof | THE BROAD INSTITUTE, INC. (US) | 2021-12-21 | — | — | US | disclosed |
| CN-113248422-A | Chiral alpha-azaarene quaternary carbon center compound, and preparation method and application thereof | 河南工业大学 | 2021-08-13 | — | — | CN | disclosed |
| US-20200109154-A1 | TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2020-04-09 | — | — | US | disclosed |
| CN-110958882-A | Tricyclic compounds as glycogen synthase kinase 3(GSK3) inhibitors and uses thereof | 布罗德研究所股份有限公司 | 2020-04-03 | — | — | CN | disclosed |
| EP-3606528-A1 | TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF | The Broad Institute, Inc. (US) | 2020-02-12 | — | — | EP | disclosed |
| WO-2018187630-A1 | TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2018-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112216-A1 | TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF | GSK3A, GSK3B, PYGB | RBBP9 2945/4885NPC1 3314/4885RAB9A 3126/4885 |
| US-11203601-B2 | Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof | GSK3A, GSK3B, PYGB | RBBP9 2945/4885NPC1 3314/4885RAB9A 3126/4885 |
| US-20200109154-A1 | TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF | GSK3A, GSK3B, PYGB | RBBP9 2945/4885NPC1 3314/4885RAB9A 3126/4885 |
| US-12486289-B2 | Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof | GSK3A, GSK3B, PYGB | RBBP9 2945/4885NPC1 3314/4885RAB9A 3126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.