Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18196943 | 0.93 | KAT6A (0.40) | KAT6AHTR6ALDH1A1TUBB4ATUBB | |
| SCHEMBL18196919 | 0.84 | HTR6 (0.40) | KAT6AHTR6SMN1; SMN2KMT2AMAPT | |
| SCHEMBL18190930 | 0.83 | LMNA (0.43) | KAT6AHTR6ALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL20530215 | 0.83 | HTR6 (0.39) | KAT6AHTR6SMN1; SMN2KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL20530234 | 0.82 | LMNA (0.42) | KAT6AHTR6ALDH1A1LMNAMAPT | |
| SCHEMBL18190928 | 0.82 | HTR6 (0.43) | KAT6AHTR6ALDH1A1KMT2A | |
| SCHEMBL18196934 | 0.82 | ALDH3A1 (0.41) | HTR6SMN1; SMN2ALDH1A1KMT2AMAPT | |
| Abeprazan SCHEMBL19385619 | 0.82 | HTR6 (0.37) | HTR6HDAC1HDAC2HDAC6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL20530183 | 0.82 | HTR6 (0.42) | KAT6AHTR6ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL20530222 | 0.81 | ALDH3A1 (0.40) | HTR6SMN1; SMN2ALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197867-B1 | NOVEL 4-METHOXY PYRROLE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAE WOONG PHARMA (KR) | 2018-11-14 | — | — | EP | disclosed |
| US-10100010-B1 | 4-methoxy pyrrole derivatives or salts thereof and pharmaceutical composition comprising the same | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2018-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10100010-B1 | 4-methoxy pyrrole derivatives or salts thereof and pharmaceutical composition comprising the same | GIPR, GRPR, HTR3E | KMT2A 3645/4885KAT6A 3538/4885HTR6 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.