Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | SELE | P16581 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535857 | 0.80 | ALDH1A1 (0.47) | ALDH1A1VCAM1HAO1HTR1AHTR3A | |
| SCHEMBL6928587 | 0.78 | CYP2A6 (0.47) | ALDH1A1ALDH1A3HTR1AHTR3AICAM1 | |
| SCHEMBL6926763 | 0.77 | ALDH1A1 (0.47) | ALDH1A1VCAM1TERTICAM1SELE | |
| SCHEMBL6929988 | 0.77 | VCAM1 (0.61) | ALDH1A1VCAM1MEN1KMT2ALMNA | |
| SCHEMBL671268 | 0.74 | ALDH1A1 (0.64) | ALDH1A1VCAM1ALDH1A3ALDH3A1TDP1 | |
| SCHEMBL29723741 | 0.74 | ALDH1A1 (0.64) | ALDH1A1VCAM1ALDH1A3ALDH3A1TDP1 | |
| SCHEMBL20535361 | 0.74 | ICAM1 (0.31) | ICAM1SELE | |
| SCHEMBL12375092 | 0.73 | TERT (0.43) | ALDH1A1HAO1TERTICAM1SELE | |
| SCHEMBL48577 | 0.72 | ALDH1A1 (1.00) | ALDH1A1VCAM1ALDH1A3KMT2AALDH3A1 | |
| SCHEMBL29364412 | 0.72 | ALDH1A1 (1.00) | ALDH1A1VCAM1ALDH1A3KMT2AALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | NAVITOR PHARMACEUTICALS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. | 2021-08-05 | — | — | US | disclosed |
| WO-2018191146-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | RHEB, KRAS, NRAS | ALDH1A1 3621/4885VCAM1 4064/4885ALDH1A3 2398/4885 |
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | RHEB, GDI2, KRAS | ALDH1A1 3277/4885VCAM1 4578/4885ALDH1A3 2289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.