Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28349758 | 1.00 | RAD52 (0.37) | RAD52PSMD14LMNANPSR1SLC6A4 | |
| SCHEMBL3881682 | 0.92 | LMNA (0.36) | RAD52PSMD14LMNANPSR1SLC6A4 | |
| Sulfuric Acid SCHEMBL1745559 | 0.85 | USP2 (0.37) | LMNANPSR1SLC6A4USP2SLC22A2 | |
| SCHEMBL1005223 | 0.82 | USP2 (0.35) | NPSR1SLC6A4USP2SLC22A2SLC22A1 | |
| Sulfuric Acid SCHEMBL7741793 | 0.82 | USP2 (0.35) | LMNANPSR1SLC6A4USP2SLC22A2 | |
| SCHEMBL398917 | 0.81 | HDAC8 (0.33) | LMNASLC6A4USP2SLC22A2SLC22A1 | |
| Sulfuric Acid SCHEMBL1745561 | 0.80 | MEN1 (0.40) | SLC6A4USP2ALDH1A1SLC22A2SLC22A1 | |
| SCHEMBL8643442 | 0.79 | PSMD14 (0.36) | RAD52PSMD14LMNANPSR1SLC6A4 | |
| Benzene SCHEMBL28004424 | 0.79 | USP2 (0.39) | RAD52PSMD14LMNANPSR1SLC6A4 | |
| Benzene SCHEMBL10400691 | 0.79 | TSHR (0.39) | RAD52PSMD14LMNANPSR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 120 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812382-B1 | METHOD FOR PRODUCING POLYISOCYANATES | BASF SE (DE) | 2013-01-23 | — | — | EP | claimed |
| US-20090112017-A1 | METHOD FOR PRODUCING POLYISOCYANATES | BASF AKTIENGESSELLSCHAFT (DE) | 2009-04-30 | — | — | US | claimed |
| EP-1812382-A1 | METHOD FOR PRODUCING POLYISOCYANATES | BASF AKTIENGESELLSCHAFT (DE) | 2007-08-01 | — | — | EP | claimed |
| WO-2006048171-A1 | METHOD FOR PRODUCING POLYISOCYANATES | BASF AKTIENGESELLSCHAFT (DE) | 2006-05-11 | — | — | WO | claimed |
| EP-0119713-B1 | LIQUID ELECTROGRAPHIC DEVELOPERS | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1987-10-07 | — | — | EP | claimed |
| EP-3705477-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2020-09-09 | — | — | EP | disclosed |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-05-26 | — | — | US | disclosed |
| EP-3216787-B1 | INTERMEDIATES FOR THE PREPARATION OF MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2020-02-19 | — | — | EP | disclosed |
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-05-16 | — | — | US | disclosed |
| US-9934911-B2 | Nonaqueous electrolyte solution and electricity storage device using same | UBE INDUSTRIES, LTD. (JP) | 2018-04-03 | — | — | US | disclosed |
| CN-107501099-A | The adjusting control agent of ATP combination cassette transporters | 沃泰克斯药物股份有限公司 | 2017-12-22 | — | — | CN | disclosed |
| EP-3216787-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2017-09-13 | — | — | EP | disclosed |
| US-4462999-A | CEPHALOSPORINS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-31 | — | — | US | disclosed |
| EP-0108977-A2 | Starting compounds for preparing 7-acylamino-3-substituted cephalosporanic acid derivatives and process for their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-05-23 | — | — | EP | disclosed |
| US-4409214-A | Including cefixime; antibiotics | FUJISAWA PHARMACEUTICAL, CO., LTD. (JP) | 1983-10-11 | — | — | US | disclosed |
| US-4409215-A | BACTERICIDES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-10-11 | — | — | US | disclosed |
| EP-0090366-A1 | 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-10-05 | — | — | EP | disclosed |
| EP-0030630-A2 | 7-Acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them; their starting compounds and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-06-24 | — | — | EP | disclosed |
| EP-0029557-A2 | 7-Acylamino-3-substituted cephalosporanic acid derivatives, processes for their preparation and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-06-03 | — | — | EP | disclosed |
| US-4025301-A | Azo dyes derived from 3-amino pyridine in hair dye compositions | SOCIETE ANONYME DITE: L'OREAL (FR) | 1977-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | RAD52 4217/4885PSMD14 2963/4885LMNA 2816/4885 |
| US-20090112017-A1 | METHOD FOR PRODUCING POLYISOCYANATES | PGLS, INMT, PNMT | RAD52 2907/4885PSMD14 2683/4885LMNA 1276/4885 |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | CFTR, ABCB1, ABCC2 | RAD52 4217/4885PSMD14 2963/4885LMNA 2816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.