Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31324689 | 0.83 | HSD17B10 (0.58) | MEN1NPC1USP2CYP1A2CYP3A4 | |
| SCHEMBL4859841 | 0.83 | HSD17B10 (0.58) | MEN1NPC1USP2CYP1A2CYP3A4 | |
| SCHEMBL27778769 | 0.82 | ALPL (0.38) | MEN1NPC1USP2CYP1A2CYP3A4 | |
| SCHEMBL1856664 | 0.82 | ALDH1A1 (0.57) | USP2NPSR1HSD17B10ALDH1A1KDM4E | |
| SCHEMBL22646258 | 0.77 | ALPL (0.62) | MEN1NPC1USP2CYP1A2CYP3A4 | |
| SCHEMBL14910385 | 0.76 | TLR8 (0.42) | MEN1NPC1MAPTALOX15RAB9A | |
| SCHEMBL22415495 | 0.76 | NPC1 (0.50) | MEN1NPC1USP2CYP1A2CYP3A4 | |
| SCHEMBL22415502 | 0.76 | ALPL (0.72) | MEN1NPC1USP2CYP1A2CYP3A4 | |
| SCHEMBL1528180 | 0.76 | ALOX15 (0.56) | MEN1NPC1USP2CYP1A2CYP3A4 | |
| SCHEMBL2056467 | 0.76 | SMN1; SMN2 (0.57) | MEN1NPC1USP2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332461-B2 | 2-(1H-pyrazol-3-yl) phenol compound and use thereof | BEIJING JIALIN PHARMACEUTICAL INC. (CN) | 2022-05-17 | — | — | US | disclosed |
| US-20200354342-A1 | 2-(1H-PYRAZOL-3-YL) PHENOL COMPOUND AND USE THEREOF | BEIJING JIALIN PHARMACEUTICAL INC. (CN) | 2020-11-12 | — | — | US | disclosed |
| EP-3705476-A1 | 2-(1H-PYRAZOL-3-YL) PHENOL COMPOUND AND USE THEREOF | Beijing Jialin Pharmaceutical Inc. (CN) | 2020-09-09 | — | — | EP | disclosed |
| US-8163729-B2 | Modulators of α7 nicotinic acetylcholine receptors and therapeutic uses thereof | WYETH (US) | 2012-04-24 | — | — | US | disclosed |
| US-20100029606-A1 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | WYETH (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11332461-B2 | 2-(1H-pyrazol-3-yl) phenol compound and use thereof | VHL, PAH, TP53 | MEN1 1057/4885NPC1 365/4885USP2 4140/4885 |
| US-20200354342-A1 | 2-(1H-PYRAZOL-3-YL) PHENOL COMPOUND AND USE THEREOF | VHL, PAH, TP53 | MEN1 1057/4885NPC1 365/4885USP2 4140/4885 |
| US-20100029606-A1 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | CHRNA7, CHRNA2, CHRNA6 | MEN1 4060/4885NPC1 1459/4885USP2 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.