Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.75 |
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.57 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12381600 | 1.00 | EPHX1 (0.75) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL10034576 | 1.00 | EPHX1 (0.75) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL10001728 | 1.00 | EPHX1 (0.75) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL6128506 | 1.00 | EPHX1 (0.75) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL291653 | 1.00 | EPHX1 (0.75) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL22361298 | 0.89 | EPHX1 (0.72) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| Hexane SCHEMBL28846476 | 0.89 | EPHX1 (0.62) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL10001727 | 0.88 | EPHX1 (0.70) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL6128484 | 0.88 | EPHX1 (0.70) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL10034575 | 0.88 | EPHX1 (0.70) | EPHX1TRPM8TRPA1TRPV1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240360075-A1 | N-SUBSTITUTED C6 CYCLYL CARBOXAMIDE COMPOUNDS AND USES THEREOF | ALCON INC. (CH) | 2024-10-31 | — | — | US | disclosed |
| WO-2024220876-A1 | N-SUBSTITUTED C6 CYCLYL CARBOXAMIDE COMPOUNDS AND USES THEREOF | ALCON INC. (CH) | 2024-10-24 | — | — | WO | disclosed |
| US-20240199564-A1 | TRPM8 AGONISTS AS COOLING AGENTS AND FOR THE TREATMENT OF DISEASE | Concentric Analgesics, Inc. | 2024-06-20 | — | — | US | disclosed |
| US-20240139087-A1 | ORGANIC COMPOUNDS AS TRPM8 ACTIVATORS | GIVAUDAN SA (CH) | 2024-05-02 | — | — | US | disclosed |
| EP-4294389-A1 | TRPM8 AGONISTS AS COOLING AGENTS AND FOR THE TREATMENT OF DISEASE | Concentric Analgesics, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-4291553-A1 | ORGANIC COMPOUNDS AS TRPM8 ACTIVATORS | Givaudan SA (CH) | 2023-12-20 | — | — | EP | disclosed |
| CN-116867775-A | Organic compounds as TRPM8 activators | 奇华顿股份有限公司 | 2023-10-10 | — | — | CN | disclosed |
| WO-2022178030-A1 | TRPM8 AGONISTS AS COOLING AGENTS AND FOR THE TREATMENT OF DISEASE | Concentric Analgesics, Inc. (US) | 2022-08-25 | — | — | WO | disclosed |
| WO-2022178030-A1 | TRPM8 AGONISTS AS COOLING AGENTS AND FOR THE TREATMENT OF DISEASE | Concentric Analgesics, Inc. (US) | 2022-08-25 | — | — | WO | disclosed |
| WO-2022170519-A1 | ORGANIC COMPOUNDS | GIVAUDAN SA (CH) | 2022-08-18 | — | — | WO | disclosed |
| US-20080255185-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2008-10-16 | — | — | US | disclosed |
| US-20080227857-A1 | N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use | WEI EDWARD TAK | 2008-09-18 | — | — | US | disclosed |
| EP-1871738-A2 | N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE | Wei, Edward T. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2007138031-A2 | MENTHANE CARBOXYLIC ACID N-(ALKYLTHIOALKYL)AMIDES AND USE THEREOF AS PHYSIOLOGICALLY ACTIVE COOLING ACTIVE INGREDIENTS | SYMRISE GMBH & CO. KG (DE) | 2007-12-06 | — | — | WO | disclosed |
| US-20070232603-A1 | Small-molecule modulators of TRP-P8 activity | DENDREON CORPORATION (US) | 2007-10-04 | — | — | US | disclosed |
| US-20070232603-A1 | Small-molecule modulators of TRP-P8 activity | DENDREON CORPORATION (US) | 2007-10-04 | — | — | US | disclosed |
| WO-2007095340-A2 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2007-08-23 | — | — | WO | disclosed |
| US-20070053834-A1 | Radioligands for the TRP-M8 receptor and methods therewith | WEI EDWARD T | 2007-03-08 | — | — | US | disclosed |
| US-20070053834-A1 | Radioligands for the TRP-M8 receptor and methods therewith | WEI EDWARD T | 2007-03-08 | — | — | US | disclosed |
| WO-2006103401-A2 | N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE | PAGET, HUGH, CHARLES, EDWARD (GB) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232603-A1 | Small-molecule modulators of TRP-P8 activity | TRPC4, TRPC3, TRPC1 | EPHX1 2888/4885TRPM8 7/4885TRPA1 22/4885 |
| US-20240199564-A1 | TRPM8 AGONISTS AS COOLING AGENTS AND FOR THE TREATMENT OF DISEASE | TRPM8, TRPM7, TRPM4 | EPHX1 3006/4885TRPM8 1/4885TRPA1 13/4885 |
| US-20240360075-A1 | N-SUBSTITUTED C6 CYCLYL CARBOXAMIDE COMPOUNDS AND USES THEREOF | TRPM8, TRPM7, TRPM2 | EPHX1 2516/4885TRPM8 1/4885TRPA1 9/4885 |
| US-20080255185-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | TRPC4, TRPC3, TRPC1 | EPHX1 2888/4885TRPM8 7/4885TRPA1 22/4885 |
| US-20070053834-A1 | Radioligands for the TRP-M8 receptor and methods therewith | GPR68, TRPM8, OPRL1 | EPHX1 4778/4885TRPM8 2/4885TRPA1 8/4885 |
| US-20080227857-A1 | N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use | TRPA1, TRPV1, CYSLTR1 | EPHX1 1517/4885TRPM8 22/4885TRPA1 1/4885 |
| US-20240139087-A1 | ORGANIC COMPOUNDS AS TRPM8 ACTIVATORS | TRPM8, TRPM7, TRPM4 | EPHX1 3242/4885TRPM8 1/4885TRPA1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.