Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20580684 | 0.91 | ALDH1A1 (0.47) | HRH4SYKHDAC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20580633 | 0.90 | GAA (0.49) | HRH4SYKHDAC1HPGDGAA | |
| SCHEMBL18975996 | 0.88 | SYK (0.39) | HRH4SYKHDAC1TSHRSMN1; SMN2 | |
| SCHEMBL20580629 | 0.82 | AR (0.49) | ALDH1A1HPGDKDM4ECASP1CASP7 | |
| SCHEMBL20581154 | 0.81 | LMNA (0.46) | SYKHDAC1HPGD | |
| SCHEMBL20581440 | 0.80 | HRH4 (0.44) | HRH4SYKTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL20581157 | 0.80 | CYP1A2 (0.47) | HDAC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL21941027 | 0.79 | ALDH1A1 (0.43) | HRH4SYKHDAC1ALDH1A1AR | |
| SCHEMBL20581339 | 0.79 | AR (0.42) | TSHRSMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL18976117 | 0.78 | GAA (0.45) | HRH4SYKHPGDGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10640507-B2 | PBD antibacterial agents | KING'S COLLEGE LONDON (GB) | 2020-05-05 | — | — | US | disclosed |
| US-20180354958-A1 | PBD ANTIBACTERIAL AGENTS | Secretary of State for Health and Social Care (GB) | 2018-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10640507-B2 | PBD antibacterial agents | OPRD1, XDH, SBDS | HRH4 13/4885SYK 3347/4885HDAC1 518/4885 |
| US-20180354958-A1 | PBD ANTIBACTERIAL AGENTS | OPRD1, XDH, SBDS | HRH4 13/4885SYK 3347/4885HDAC1 518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.