Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21941027 | 0.92 | ALDH1A1 (0.43) | SYKHRH4ACKR3HDAC1LEF1 | |
| SCHEMBL18976117 | 0.91 | GAA (0.45) | SYKHRH4HPGDGAAPRKDC | |
| SCHEMBL20581237 | 0.88 | HRH4 (0.43) | SYKHRH4HDAC1TSHRSMN1; SMN2 | |
| SCHEMBL22824938 | 0.86 | HDAC1 (0.43) | ACKR3HDAC1LEF1ACHEBACE1 | |
| SCHEMBL18314047 | 0.86 | LEF1 (0.44) | ACKR3HDAC1LEF1ALDH1A1KDM4E | |
| SCHEMBL18976489 | 0.84 | AR (0.41) | ALDH1A1KDM4EHPGDCASP1CASP7 | |
| SCHEMBL21941140 | 0.83 | LMNA (0.42) | SYKACKR3HDAC1LEF1ACHE | |
| SCHEMBL18976466 | 0.82 | HRAS (0.41) | SYKHRH4SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL27118694 | 0.82 | LEF1 (0.38) | HDAC1LEF1ACHEBACE1PRKDC | |
| SCHEMBL21941146 | 0.82 | CYP1A2 (0.43) | ACKR3HDAC1LEF1HPGDACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10640507-B2 | PBD antibacterial agents | KING'S COLLEGE LONDON (GB) | 2020-05-05 | — | — | US | disclosed |
| WO-2017098257-A1 | PBD ANTIBACTERIAL AGENTS | KING'S COLLEGE LONDON (GB) | 2017-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10640507-B2 | PBD antibacterial agents | OPRD1, XDH, SBDS | SYK 3347/4885HRH4 13/4885ACKR3 1205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.