Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 7/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | BAX | Q07812 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL50452 | 0.96 | LMNA (0.57) | LMNALTA4HTSHRNPY5RNR1H2 | |
| Diphenylether SCHEMBL28593325 | 0.94 | LMNA (0.55) | LMNALTA4HTSHRNPY5RNR1H2 | |
| Diphenylether SCHEMBL6560849 | 0.89 | NPY5R (0.49) | LMNALTA4HNPY5RPTGS1KDM4E | |
| Diphenylether SCHEMBL896711 | 0.88 | NPY5R (0.51) | LMNALTA4HTSHRNPY5RPTGS1 | |
| Diphenylether SCHEMBL3797141 | 0.87 | LTA4H (0.47) | LMNALTA4HTSHRNPY5RNR1H2 | |
| Diphenylether SCHEMBL8691831 | 0.87 | LTA4H (0.67) | LMNALTA4HTSHRNR1H2BAX | |
| Diphenylether SCHEMBL7865304 | 0.85 | LMNA (0.47) | LMNALTA4HTSHRNPY5RNR1H2 | |
| Diphenylether SCHEMBL20590366 | 0.84 | LTA4H (0.59) | LMNALTA4HTSHRNPY5RKDM4E | |
| Diphenylether SCHEMBL3248800 | 0.84 | LTA4H (0.63) | LMNALTA4HTSHRNR1H2BAX | |
| Diphenylether SCHEMBL23494789 | 0.82 | TGM2 (0.47) | LMNALTA4HNPY5RPTGS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691995-B1 | ABSORBENT POLYMER HAVING REDUCED DUSTING TENDENCIES | DOW CHEMICAL CO (US) | 2000-04-12 | — | — | EP | disclosed |