Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 9/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | BAX | Q07812 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL50452 | 0.89 | LMNA (0.57) | LMNAALDH1A1LTA4HTSHRNPY5R | |
| Diphenylether SCHEMBL8373541 | 0.88 | LTA4H (0.49) | LMNAALDH1A1RECQLLTA4HTSHR | |
| Diphenylether SCHEMBL28593325 | 0.87 | LMNA (0.55) | LMNAALDH1A1LTA4HTSHRNPY5R | |
| Diphenylether SCHEMBL514872 | 0.87 | ALDH1A1 (0.60) | ALDH1A1RECQLLTA4HTSHRNR1H2 | |
| Propylene Glycol SCHEMBL3797143 | 0.86 | ALDH1A1 (0.58) | LMNAALDH1A1RECQLRAB9ATDP1 | |
| Diphenylether SCHEMBL8049569 | 0.85 | LMNA (0.53) | LMNALTA4HTSHRNPY5RKDM4E | |
| Diphenylether SCHEMBL15348001 | 0.85 | ALDH1A1 (0.54) | ALDH1A1RECQLLTA4HTSHRNR1H2 | |
| Diphenylether SCHEMBL20590366 | 0.85 | LTA4H (0.59) | LMNAALDH1A1RECQLLTA4HTSHR | |
| Tetraethylene Glycol SCHEMBL2481799 | 0.85 | ALDH1A1 (0.58) | ALDH1A1RECQLLTA4HTSHRNR1H2 | |
| Diphenylether SCHEMBL148065 | 0.85 | ALDH1A1 (0.58) | ALDH1A1RECQLLTA4HTSHRNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119591-A1 | CONCENTRATED STRIPPER COMPOSITION AND METHOD | S.C. Johnson Commercial Markets, Inc. (US) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020518-A1 | CONCENTRATED STRIPPER COMPOSITION AND METHOD | S.C. JOHNSON COMMERCIAL MARKETS, INC. (US) | 2000-04-13 | — | — | WO | disclosed |