SCHEMBL20612908

SCHEMBL20612908

O=C1Cc2c(OCC3CCN(c4c(F)cc(Cl)cc4F)CC3)ccc(Cl)c2N1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 6/20 0.41
FFAR4 Q5NUL3 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20613102 0.88 TRPV4 (0.40) MGLL
SCHEMBL20613099 0.86 FFAR4 (0.42) MGLLFFAR4
SCHEMBL25968580 0.83 FFAR4 (0.42) MGLLFFAR4
SCHEMBL25969246 0.82 MGLL (0.39) MGLL
SCHEMBL20597008 0.78 TRPV4 (0.35)
SCHEMBL25969105 0.77 MGLL (0.44) MGLLFFAR4
SCHEMBL20597385 0.77 TRPV4 (0.37)
SCHEMBL20612971 0.76 HTR2A (0.39) FFAR4
SCHEMBL20612870 0.75 MGLL (0.41) MGLL
SCHEMBL17543790 0.73 PTPN11 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3421454-A1 PIPERIDINE DERIVATIVE Otsuka Pharmaceutical Co., Ltd. (JP) 2019-01-02 EP disclosed