Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632804 | 0.86 | KDM1A (0.38) | TRPA1TRPV3TRPV4ADORA2AALDH1A1 | |
| SCHEMBL20632004 | 0.85 | PHGDH (0.36) | TRPV4ADORA2AACP1CTSKKCNH2 | |
| SCHEMBL20631944 | 0.80 | KDM1A (0.32) | GRIN1KDM1A | |
| SCHEMBL20633094 | 0.79 | PIK3CD (0.33) | ACP1MEN1KMT2AITGB3ITGA2B | |
| SCHEMBL20631488 | 0.79 | GRIN1 (0.34) | ALDH1A1ACP1CTSKKCNH2MAPK14 | |
| SCHEMBL20633173 | 0.77 | ACP1 (0.33) | TRPA1TRPV3TRPV4ADORA2AALDH1A1 | |
| SCHEMBL20633233 | 0.75 | KMT2A (0.36) | TRPA1TRPV3TRPV4ADORA2AALDH1A1 | |
| SCHEMBL17655381 | 0.73 | SMN1; SMN2 (0.39) | TRPA1TRPV3TRPV4ADORA2AALDH1A1 | |
| SCHEMBL20632404 | 0.72 | GAA (0.38) | TRPV4ACP1KMT2AMAPK14 | |
| SCHEMBL20632425 | 0.71 | NR3C1 (0.37) | TRPA1TRPV3TRPV4ADORA2AITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |