Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632804 | 0.87 | KDM1A (0.38) | KMT2AHPGDKDM4ESMN1; SMN2TRPA1 | |
| SCHEMBL20632425 | 0.87 | NR3C1 (0.37) | TRPA1ADORA2ACNR2KDM1AFYN | |
| SCHEMBL20633441 | 0.84 | FYN (0.39) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL20632673 | 0.83 | CA2 (0.36) | KDM4ESMN1; SMN2ALDH1A1ADORA2ACNR2 | |
| SCHEMBL20633005 | 0.82 | LMNA (0.38) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL20632705 | 0.82 | PHGDH (0.41) | HPGDKDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL20631944 | 0.81 | KDM1A (0.32) | PKMKDM1A | |
| SCHEMBL20633162 | 0.81 | AURKA (0.38) | KMT2ASMN1; SMN2MEN1ALDH1A1TDP1 | |
| SCHEMBL20632477 | 0.81 | KDM1A (0.34) | HPGDKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL20632922 | 0.81 | KDM4E (0.36) | KMT2AHPGDKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |