Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632146 | 0.85 | TRPA1 (0.35) | ACP1CTSKKCNH2AKT1MAPK14 | |
| SCHEMBL20631488 | 0.82 | GRIN1 (0.34) | PHGDHACP1CTSKKCNH2MAPK14 | |
| SCHEMBL20633173 | 0.81 | ACP1 (0.33) | ACP1CTSKKCNH2AKT1CTSB | |
| SCHEMBL20632313 | 0.77 | PHGDH (0.33) | PHGDHKDREGFRFGFR1ACP1 | |
| SCHEMBL20632404 | 0.76 | GAA (0.38) | KDREGFRACP1MAPK11MAPK14 | |
| SCHEMBL20632673 | 0.74 | CA2 (0.36) | CA2CA9ADORA2AFYN | |
| SCHEMBL20633401 | 0.74 | HTR2C (0.42) | PHGDHKDREGFRFGFR1ACP1 | |
| SCHEMBL20632922 | 0.73 | KDM4E (0.36) | KDRACP1CA2CA9CTSK | |
| SCHEMBL20633441 | 0.73 | FYN (0.39) | KDRCA2CA9FYNTRPV4 | |
| SCHEMBL20633005 | 0.73 | LMNA (0.38) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |