Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 7/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.51 |
| ▸ | HTR3B | O95264 | 4/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17531156 | 0.89 | KDM4E (0.42) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL5205003 | 0.79 | PRKCQ (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL25281732 | 0.77 | PARP1 (0.40) | KDM4EALDH1A1HPGDTSHRCYP1A2 | |
| SCHEMBL17164737 | 0.76 | HTR3A (0.58) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL15228263 | 0.76 | HTR3A (0.54) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL26181996 | 0.76 | HTR3A (0.54) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL3120227 | 0.75 | NOS3 (0.38) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL6350054 | 0.75 | HTR3E (0.49) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL13553012 | 0.74 | ADRB1 (0.53) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL17531163 | 0.74 | ALDH1A1 (0.50) | KDM4EHSD17B10ALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |