Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20633297 | 0.90 | PHGDH (0.36) | SCN9ASLC5A1NPY2RIDH2CDK4 | |
| SCHEMBL20632641 | 0.89 | ALOX15 (0.35) | SCN9ARPS6KB1FAAHSLC5A1IDH2 | |
| SCHEMBL20631665 | 0.88 | SLC9A1 (0.35) | FAAHCDK5CDK5R1CHRNB2CHRNB4 | |
| SCHEMBL20632826 | 0.85 | FAAH (0.33) | FAAHCDK5CDK5R1GRIN2BCHRNB2 | |
| SCHEMBL16775973 | 0.84 | MPL (0.44) | MPLFYNSCN9ARPS6KB1FAAH | |
| SCHEMBL20633332 | 0.83 | SLC9A1 (0.35) | FAAHCDK5CDK5R1MTORCHRNB2 | |
| SCHEMBL20631437 | 0.83 | KDM1A (0.36) | NPY2RIDH2GRIN1GRIN2B | |
| SCHEMBL20633275 | 0.82 | ALOX15 (0.41) | SCN9ARPS6KB1IDH2 | |
| SCHEMBL20632293 | 0.82 | L3MBTL1 (0.44) | RPS6KB1NPY2RIDH2GSK3B | |
| SCHEMBL20633316 | 0.81 | OPRK1 (0.35) | SCN9ARPS6KB1FAAHMTORGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |